Different Crystalloids on AKI in Shock

• Conditions: Shock
• Interventions: Other: Fluid resuscitation

• Registration Number: NCT03155126
• Lead Sponsor: Southeast University, China

Brief Summary

The goal is to observe that the incidence of acute kidney injury in patients who need fluid resuscitation when resuscitated with saline or acetated Ringer's sodium.

Detailed Description

Fluid resuscitation is important to shock patients. Saline is the classical fluids for resuscitation. However, studies showed that resuscitation with saline could increase the incidence of hyperchloremia and acute kidney injury. Thus, the goal is to observe that the incidence of acute kidney injury in patients who need fluid resuscitation when resuscitated with saline or acetated Ringer's sodium.

Study Timeline

• Study First Submitted: 2017-05-11
• Study First Submitted QC: 2017-05-15
• Study First Posted: 2017-05-16
• Status Verified: 2017-06
• Study Start: 2017-06
• Last Update Submitted: 2017-06-13
• Last Update Posted: 2017-06-14
• Primary Completion: 2018-06
• Study Completion: 2018-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

• Shock patients who need fluid resuscitation with risk factors of acute kidney injury

Exclusion Criteria

• Patients with a history of chronic kidney injury and hemodialysis therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Saline group	Fluid resuscitation	Patients resuscitated with saline
Acetated Ringer's sodium group	Fluid resuscitation	Patients resuscitated with Acetated Ringer's sodium

Primary Outcome Measures

Name	Time	Method
Incidence of acute kidney injury	28 day	Incidence of acute kidney injury

Secondary Outcome Measures

Name	Time	Method
Application of renal replacement	28 day	Application of renal replacement

Trial Locations

Locations (1)

Zhongda Hospital Southeast University; 🇨🇳 Nanjing, Jiangsu, China