Correlations Between Biopsy Verified Myocardial Fibrosis and Echocardiography Parameters in Patients With Severe Aortic Stenosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Echocardiography parameters of systolic and diastolic function
研究概览
简要总结
Patients with aortic stenosis waiting for aortic valve repair were investigated with echocardiography preoperatively, and a myocardial biospy was taken during the operation. The investigators aim to perform a retrospective analysis of these data, to look for correlations between biopsy-verified myocardial fibrosis and echocardiography parameters.
The patients also had cardiac magnetic resonance imaging performed, for a non-invasive quantification of myocardial fibrosis.
详细描述
The primary purpose of the study is to retrospectively compare echocardiography measurements with a myocardial biopsy taken perioperatively in patients with aortic stenosis requiring aortic valve replacement.
Echocardiography and endomyocardial biopsy have been performed in close proximity in time. Due to a small sample size and a large number of echocardiography measurements being possible, only a limited number of prespecified comparisons are performed.
Cardiac magnetic resonance (CMR) was also performed in patients without contraindication, providing a non-invasive gold standard for diffuse fibrosis and replacement fibrosis. A secondary goal will be to investigate how echocardiography parameters performs compared to CMR in quantifying myocardial fibrosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Planned for aortic valve replacement for symptomatic, severe aortic stenosis
排除标准
- •Previous myocardial infarction / coronary disease that can cause fibrosis
- •Do not wish to participate in study
研究组 & 干预措施
Aortic stenosis without biopsy-verified myocardial fibrosis
Periopererative echocardiography
干预措施: Transthoracic echocardiography (Diagnostic Test)
Aortic stenosis with biopsy-verified myocardial fibrosis
Periopererative echocardiography
干预措施: Transthoracic echocardiography (Diagnostic Test)
Aortic stenosis with biopsy-verified myocardial fibrosis
Periopererative echocardiography
干预措施: Cardiac magnetic resonance imaging (Diagnostic Test)
Aortic stenosis without biopsy-verified myocardial fibrosis
Periopererative echocardiography
干预措施: Cardiac magnetic resonance imaging (Diagnostic Test)
结局指标
主要结局
Echocardiography parameters of systolic and diastolic function
时间窗: Time between echocardiography exam and endomyocardial biopsy was kept as short as possible, and not more than one month apart. If no cardiac event had happened in between, echocardiography and biopsy could be regarded as being taken at the same time.
Echocardiograhic parameters on structure and function of the heart, as described in guidelines for echocardiography assessment: Basal hypertrophy of interventricular septum, in mm. LV end diastolic mass (preferably from 3D volume of LV) LV end diastolic mass, indexed (preferably from 3D volume of LV) Left ventricular global longitudinal strain (%) Left ventricular ejection fraction, 3D Left ventricular septal strain rate, peak systolic, sample placed in basal septum Grading of diastolic dysfunction (ref EACVI/ASE guidelines) Left atrial strain, reservoir function, biplane Left atrial strain, conduit function , biplane Left atrial strain, (atrial) contraction phase, biplane Severity of aortic stenosis, evaluated by echocardiography (mild, moderate, severe)
Echocardiography parameters of systolic and diastolic function
时间窗: The time between echocardiography exam and endomyocardial biopsy was kept as short as possible, and not more than one month apart. If no cardiac event had happened in between, we could now regard echocardiography and biopsy being taken at the same time.
Echocardiograhic parameters on structure and function of the heart, as described in guidelines for echocardiography assessment: Basal hypertrophy of interventricular septum, in mm. LV end diastolic mass (preferably from 3D volume of LV) LV end diastolic mass, indexed (preferably from 3D volume of LV) Left ventricular global longitudinal strain (%) Left ventricular ejection fraction, 3D Left ventricular septal strain rate, peak systolic, sample placed in basal septum Grading of diastolic dysfunction (ref EACVI/ASE guidelines) Left atrial strain, reservoir function, biplane Left atrial strain, conduit function , biplane Left atrial strain, (atrial) contraction phase, biplane Severity of aortic stenosis, evaluated by echocardiography (mild, moderate, severe)
次要结局
- CMR parameters of systolic and diastolic function(CMR was taken preoperatively, and at 1-year postoperative check-up)