A clinical and experimental study to compare the four types of virechana karma (Purgation Therapy) i.e Anulomana-By Haritaki, Sramsana-By Aragwadha, Bhedana-By Katuki,Rechana-By Trivrit and their efficacy in the management of Ekakushtha (Psoriasis).
- Conditions
- Patients suffering from psoriasis
- Registration Number
- CTRI/2012/04/002583
- Lead Sponsor
- I P G T R A
- Brief Summary
The purpose of the study is 1. To compare the four types of Virechana Karma ( Purgation therapy) i.e Anulomana, Sramsana, Bhedana and Rechana in patients of Ekakushtha (Psoriasis). 2. To compare the efficacy of four types of Virechana Karma on Ekakushtha (Psoriasis). **Method of research:** Patients of psoriasis will be selected based on inclusion & exclusion criteria from O.P.D & I.P.D of I.P.G.T & R.A Hospital, Jamnagar, irrespective of religion, sex, occupation, cast etc. They will be randomly divided into 4 groups, Group A (*Anulomana* group), Group B (*Sramsana* group), Group C (*Bhedana* group) and Group D (*Rechana* group).
**Interventions**
**Group A**
*Deepana* & *Pachana* with *Trikatu Choorna* 2gm b.d for 2 days.
*Snehapana* with *Murchita* *goghrita* till *samyak* *snigdha* *lakshanas*
*Abhyanga* & *Ooshmasweda* for 3 days
*Virechana* with *Anulomana* drug (*Hareetaki-Terminalia chebula Retz*)
*Samsarjana* krama.
**Group B**
*Deepana* & *Pachana Trikatu Choorna* 2gm b.d for 2 days
*Snehapana* with *Murchita* *goghrita* till *samyak* *snigdha* *lakshanas*
*Abhyanga* & *Ooshmasweda* for 3 days
*Virechana* with *Sramsana* drug (*Aragwadha-Cassia fistula Linn*)
*Samsarjana* *krama*.
**Group C**
*Deepana* & *Pachana Trikatu Choorna* 2gm b.d for 2 days
*Snehapana* with *Murchita* *goghrita* till *samyak* *snigdha* *lakshanas*
*Abhyanga* & *Ooshmasweda* for 3 days
*Virechana* with *Bhedana* drug (*Katuki-Picrorhiza kurroa Royle ex Benth*)
*Samsarjana* *krama*.
**Group D**
*Deepana* & *Pachana Trikatu Choorna* 2gm b.d for 2 days
*Snehapana* with *Murchita* *goghrita* till *samyak* *snigdha* *lakshanas*
*Abhyanga* & *Ooshmasweda* for 3 days
*Virechana* with *Rechana* drug (*Trivriti-Operculina turpethum Linn*)
*Samsarjana* *krama*.
**Selection of Drug:**
*Trikatu choorna for Deepana & Pachana*
*Murchita* *goghrita* for *snehapana*.
*Murchita* *tila* *taila* for *abhyanga*
*Haritaki* (Terminalia chebula Retz) fruit – for *Anulomana*
*Aragwadha* (Cassia fistula Linn) fruit pulp – for *Sramsana*
*Katuki* (Picrorhiza kurroa Royle ex Benth) rhizome – for *Bhedana*
*Trivrit* (Operculina turpethum Linn) root – for *Rechana*
**Dose:**
*Haritaki* - 25-50gms
*Aragwadha* – 25 -50gms
*Katuki* – 10-30gms
*Trivrit* – 10-30gms
*Kwatha (Decoction)* of above drugs will be prepared by the classical method and used for *Virechana*. *Aragwadha* will be administered in the form of *Phanta* (Hot effusion).
**Duration of study:** 15-20 days
**Laboratory investigations:**
1. Routine Blood, Urine and Stool investigations before & after treatment will be done.
2. Biochemical investigations - Blood Sugar, Lipid profile, Serum Bilirubin, Total Proteins, LFT, RFT, and Serum electrolytes will be done before &after treatment
**Assessment Criteria:**
**Assessement of Virechana**
- *Shuddhi* will be assessed based on *Vaigiki* *shuddhi* (number of *vegas*), *Maniki* *shuddhi* (quantity of faeces), *Laingiki* *shuddhi* (signs and symptoms of proper *Virechana*) and *Antiki* *shuddhi* ( *malanta*, *pittanta*, *kaphanta* & *vatanta*).
- Time of administration of *Virechana* drug & time of onset of first vega.
- Total duration of *Virechana*.
- Haematological, urine, stool & biochemical investigations will be done before treatment & after treatment.
**Assessment of response of therapy on Psoriasis**
The improvement provided by different types of *Virechana* will be assessed on the basis of relief in signs & symptoms. All the signs & symptoms will be assigned scores depending upon their severity to assess the effect objectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- All
- Target Recruitment
- 100
- 1.Patients with all forms of Psoriasis who are clinically fit to undergo Virechana procedure.
- 2.Age- 17 to 60 years 3.Sex- Both sexes 4.Patients having Madhyma Koshtha.
- 1.Clinically unfit for Virechana.
- 2.Age <17yrs & >60yrs.
- 3.Patients having Mridu & Krura Koshtha.
- 4.Pregnant lady 5.Any other serious systemic illness 6.Patient not willing for treatment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -Time of administration of Virechana drug & time of onset of first vega. Assessment will be done during the time of Virechana. Assessment of Virechana Assessment will be done during the time of Virechana. -Based on Vaigiki shuddhi , Maniki shuddhi, Laingiki shuddhi and Antiki shuddhi. Assessment will be done during the time of Virechana. -Total duration of Virechana. Assessment will be done during the time of Virechana. -Effect of four types of Virechana on Hematological and bio-chemical parameters. Assessment will be done during the time of Virechana.
- Secondary Outcome Measures
Name Time Method 1.Improvements in signs and symptoms of Psoriasis. 2. Improvements in Dermatology Life Quality Index.
Related Research Topics
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Trial Locations
- Locations (1)
Department of Panchakarma, IPGT & RA Hospital Jamnagar
🇮🇳Jamnagar, GUJARAT, India
Department of Panchakarma, IPGT & RA Hospital Jamnagar🇮🇳Jamnagar, GUJARAT, IndiaDr Vikram KumarPrincipal investigator919574937714vikramkumar83@gmail.com