Development and Validation of a Tumour Oxygenation Monitoring Probe
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Count of MRIs Successfully Modelled for Oxygen Correlation
研究概览
简要总结
Laboratory based study in which novel tissue oxygenation probe with the potential provide novel means for assessing response to cancer treatment will be developed and validated.
详细描述
Tumour hypoxia is feature common to most solid tumours, with significant implications in tumour aggressiveness, metastatic potential and response to therapy. Tumour oxygenation monitoring is likely, therefore, to provide a valuable adjunct in risk stratification and treatment response monitoring.
Diffuse reflectance spectroscopy (DRS) utilises the differing absorption of oxygenated as compared to deoxygenated haemoglobin to provide an accurate measure of tissue oxygenation.
This project aims to develop and validate a tissue oxygenation probe for cancer monitoring. Using the clinical paradigms of rectal and breast cancer, anonymised MRIs of cancer sufferers will guide simulations of tissue optical properties to develop a DRS probe. The 3D reconstructed sans will then be used to 3D print tissue phantom models on which the DRS probe will be validated against reference bench top analysers.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •MRIs from Breast or Rectal Cancer patients (10 of each)
- •Locally advanced Cancers (Stage 2 or 3)
- •Patients who went on to receive neoadjuvant chemoradiotherapy.
- •Anonymised scans
排除标准
- •MRIs from patients under the age of 18, or older than 99 years old will be excluded.
- •MRIs from patients who did not receive neoadjuvant therapy for cancer will be excluded.
结局指标
主要结局
Count of MRIs Successfully Modelled for Oxygen Correlation
时间窗: MRIs were 3D modelled - single time point at time of MRI
Number of MRIs 3D modelled for oxygenation sensor development Note: this outcome measure was orginally expressed as "Oxygenation Correlation" though this was modeled and therefore we have expressed it as above
次要结局
未报告次要终点