Morphofunctional Imaging and Developmental Dyslexia

Completed

• Conditions: Developmental Dyslexia
• Interventions: Procedure: Morphological and functional MRI

• Registration Number: NCT00254644
• Lead Sponsor: University Hospital, Tours

Brief Summary

Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. They are compared to control adults paired with age and laterality. To study phonological treatment, the researchers used functional magnetic resonance imaging (fMRI) with a rime judgement task and silent word generation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2005-11-15
• Study First Submitted QC: 2005-11-15
• Study First Posted: 2005-11-16
• Study Start: 2007-02
• Primary Completion: 2008-02
• Study Completion: 2008-02
• Status Verified: 2011-05
• Last Update Submitted: 2017-01-13
• Last Update Posted: 2017-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

• Developmental dyslexia according to Critchley.
• Normal performance intelligence quotient (PIQ)
• Age: 18-35 years
• Sex: Male
• Right handed
• No hearing deficit.

Exclusion Criteria

• No head injury
• No attention deficit hyperactivity disorder (ADHD)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control	Morphological and functional MRI	adults from 18-35 ans.
Dyslexia	Morphological and functional MRI	adults from 18-35 ans.

Primary Outcome Measures

Name	Time	Method
Cortical thickness	2 years	The average cortical thickness maps of healthy subjects and dyslexic will be compared hemisphere by hemisphere. This will identify whether there are cortical areas including cortical thickness differed significantly between normal and dyslexic.ts of different ages

Secondary Outcome Measures

Name	Time	Method
Average cortical thickness	2 years	For each group, cortical thickness maps of average left and right hemispheres are compared. This will identify whether there is an asymmetry left / right in terms of cortical thickness in normal subjects and dyslexic.

Trial Locations

Locations (1)

CHU; 🇫🇷 Tours, France