To compare two advanced high-precision radiotherapy techniques in head and neck cancers.

Phase 2

Completed

• Registration Number: CTRI/2008/091/000045
• Lead Sponsor: Tata Memorial Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

1)Age > 18 and < 65
2)Biopsy proven squamous cell carcinoma of the oropharynx.
3)AJCC stage T1-3, N0-N2b, M0 patients with pre-treatment tumor measurements clinically as well as on CT/MRI scans.
4)Surgery of the primary tumor limited to excisional or incisional biopsy.
5)No form of neck dissection for nodal metastases.
6)KPS >=60
7)No prior history of therapeutic irradiation
8)Patient willing and reliable for follow-up
9)Patients nutritional & physical condition compatible with planned therapy
10)Signed study specific consent form

Exclusion Criteria

1)Evidence of distant metastasis
2)Previous therapeutic irradiation for head & neck cancer or any other invasive cancer other than squamous or basal cell carcinoma of the skin
3)History of prior malignancy
4)Prophylactic use of amifostine or pilocarpine
5)Active untreated infection like tuberculosis, which preclude the use of systemic chemotherapy or wound interfere with completion of the treatment
6)Any histopathology other than squamous carcinoma
7)Primary nasopharyngeal carcinoma
8)Age <18 or > 65 years
9)Pregnancy or lactating

Study & Design

• Study Type: Interventional
• Study Design: Not specified