Measurement of Mean Systemic Filling Pressure & Stressed Volume With CardioQ+® Oesophageal Doppler Measurement
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiac Surgery
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Enrollment
- 42
- Locations
- 1
- Primary Endpoint
- MSFPhold
- Last Updated
- 6 years ago
Overview
Brief Summary
To study the reliablity of MSFP and stressed volume to follow volume loading and to predict fload loading responsiveness in patients after elective coronary artery bypass grafting (CABG) surgery.
Detailed Description
In this study the oesophageal Doppler monitor (CardioQ+), arterial pulse wave analysis (via the CardioQ+ and Flotrac device) and central venous pressure (CVP) will be used to estimate mean systemic filling pressure (MSFP) with the inspiratory hold method. Furthermore the MSFParm will be determined using a rapid cuff inflator. From MSFP vascular compliance (Csys) and stressed volume (Vs) will be calculated. The accuracy of Vs to follow a 500 increase in volume will be studied. The accuracy of MSFP and Vs to to predict fluid loading responsiveness will be assessed in 42 patients after elective coronary artery bypass grafting (CABG) surgery. The effect of a standardised fluid loading on parameters of intrinsic contractility and afterload will be determined. The effect of fluid loading on inertia, resistance and elastance will be assessed
Investigators
D.P.Veelo
MD PhD
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Eligibility Criteria
Inclusion Criteria
- •Patients 18 years and older planned for CABG
Exclusion Criteria
- •Contraindication for fluid loading
- •Pregnancy, morbid obesity
- •Hemodynamic instability with a mean arterial pressure (MAP) \< 55 mm Hg and/ or a cardiac index \< 1.5 L•min-1
- •Severe arrhythmias
- •Intra-cardiac shunts
- •Symptomatic peripheral vascular disease
- •Symptomatic pulmonary disease
- •Significant valvular regurgitation
- •Poor pre-operative left or right ventricular function
- •Core temperature \< 36 °C
Outcomes
Primary Outcomes
MSFPhold
Time Frame: Before and after fluid administration (2 minutes and 10 minutes)
Mean systemic filling pressure
MSFParm
Time Frame: Before and after fluid administration (2 minutes and 10 minutes)
Mean systemic filling pressure
Secondary Outcomes
- Stressed volume(Before and after fluid administration (2 minutes and 10 minutes))