Measurement of Mean Systemic Filling Pressure & Stressed Volume With CardioQ+® Oesophageal Doppler Measurement
试验速览
- 阶段
- 不适用
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- MSFPhold
研究概览
简要总结
To study the reliablity of MSFP and stressed volume to follow volume loading and to predict fload loading responsiveness in patients after elective coronary artery bypass grafting (CABG) surgery.
详细描述
In this study the oesophageal Doppler monitor (CardioQ+), arterial pulse wave analysis (via the CardioQ+ and Flotrac device) and central venous pressure (CVP) will be used to estimate mean systemic filling pressure (MSFP) with the inspiratory hold method. Furthermore the MSFParm will be determined using a rapid cuff inflator. From MSFP vascular compliance (Csys) and stressed volume (Vs) will be calculated.
The accuracy of Vs to follow a 500 increase in volume will be studied. The accuracy of MSFP and Vs to to predict fluid loading responsiveness will be assessed in 42 patients after elective coronary artery bypass grafting (CABG) surgery. The effect of a standardised fluid loading on parameters of intrinsic contractility and afterload will be determined. The effect of fluid loading on inertia, resistance and elastance will be assessed
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years and older planned for CABG
排除标准
- •Contraindication for fluid loading
- •Pregnancy, morbid obesity
- •Hemodynamic instability with a mean arterial pressure (MAP) < 55 mm Hg and/ or a cardiac index < 1.5 L•min-1
- •Severe arrhythmias
- •Intra-cardiac shunts
- •Symptomatic peripheral vascular disease
- •Symptomatic pulmonary disease
- •Significant valvular regurgitation
- •Poor pre-operative left or right ventricular function
- •Core temperature < 36 °C
- •Contra-indication to the rapid cuff inflator
- •Contra-indication to oesophageal Doppler probe insertion.
结局指标
主要结局
MSFPhold
时间窗: Before and after fluid administration (2 minutes and 10 minutes)
Mean systemic filling pressure
MSFParm
时间窗: Before and after fluid administration (2 minutes and 10 minutes)
Mean systemic filling pressure
次要结局
- Stressed volume(Before and after fluid administration (2 minutes and 10 minutes))
研究者
D.P.Veelo
MD PhD
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)