Stimulate the Ketogenesis by Using a Caffeine Supplement
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Plasma Acetoacetate Concentrations
研究概览
简要总结
Evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10).
详细描述
The aim of the study is to evaluate the effect of a caffeine supplement on the stimulation of lipolysis and the production of ketones in healthy adults (N=10). Two different doses of caffeine (2.5 mg/kg of BW and 5 mg/kg of BW) are compared. All the participants have to follow three sequential visits of four hours each, which included a breakfast with one of the doses (2.5 or 5 mg/kg) of the caffeine supplement or without any supplement (baseline) and repeated blood sampling in order to evaluate ketone concentrations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults
- •18 years old and over
排除标准
- •Drinking more than 300 mg of caffeine per day
- •Diabetes or prediabetes
- •Abnormal liver and kidney function
- •Uncontrolled dyslipidemia, blood pressure
- •Use of drugs known to influence the metabolism of lipids and carbohydrates (steroid, beta-blockers, diuretics, insulin sensitizer, etc.)
- •Severe inflammation or infection
- •Pregnancy
结局指标
主要结局
Plasma Acetoacetate Concentrations
时间窗: 4 hours
Plasma acetoacetate (µmol/L) measured over a 4 hour period.
Plasma Beta-hydroxybutyrate Concentrations
时间窗: 4 hours
Plasma beta-hydroxybutyrate (µmol/L) measured over a 4 hour period.
次要结局
- Plasma Triglyceride Concentrations(4 hours)
- Plasma Glucose Concentrations(4 hours)
- Plasma Cholesterol Concentrations(4 hours)