AGR+PNI as Predictors of Systemic Lupus Erythematosus Disease Activity

Not yet recruiting

• Conditions: Systemic Lupus Erythematosus Disease

• Registration Number: NCT07043153
• Lead Sponsor: Sohag University

Brief Summary

This study aims to evaluate the clinical utility of combining the albumin to globulin ratio (AGR) and the prognostic nutritional index (PNI) as a predictive model for assessing disease activity in patients with systemic lupus erythematosus (SLE). By correlating these nutritional and inflammatory markers with clinical manifestations and laboratory parameters, we hope to establish a simple, non-invasive, and cost-effective tool to aid in monitoring disease activity in Systemic lupus erythematosus patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-06
• Study First Submitted: 2025-06-19
• Study First Submitted QC: 2025-06-26
• Last Update Submitted: 2025-06-26
• Study First Posted: 2025-06-29
• Last Update Posted: 2025-06-29
• Study Start: 2025-08-01
• Primary Completion: 2026-05
• Study Completion: 2026-05-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

• · Age ≥ 18 years.

  • Both sexes.
  • Patients diagnosed with SLE who fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria and matched controls.

Exclusion Criteria

• Co-existing chronic inflammatory or autoimmune diseases.
• Age <18 years
• Malignancy.
• Pregnancy or lactation.
• Chronic liver or renal insufficiency.
• Malignant hematologic diseases.
• Active hepatitis.
• Acute infection within the previous four weeks

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
assess the utility of the albumin-to-globulin ratio (AGR) as reliable, non-invasive biomarker for predicting disease activity in patients with systemic lupus erythematosus (SLE).	From 6 month to one year

Trial Locations

Locations (1)

Sohag University hospitals; 🇪🇬 Sohag, Egypt