Using Combination of Albumin to Globulin Ratio and Prognostic Nutritional Index Model for Predicting Disease Activity in Patients With Systemic Lupus Erythematosus
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- assess the utility of the albumin-to-globulin ratio (AGR) as reliable, non-invasive biomarker for predicting disease activity in patients with systemic lupus erythematosus (SLE).
研究概览
简要总结
This study aims to evaluate the clinical utility of combining the albumin to globulin ratio (AGR) and the prognostic nutritional index (PNI) as a predictive model for assessing disease activity in patients with systemic lupus erythematosus (SLE). By correlating these nutritional and inflammatory markers with clinical manifestations and laboratory parameters, we hope to establish a simple, non-invasive, and cost-effective tool to aid in monitoring disease activity in Systemic lupus erythematosus patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •· Age ≥ 18 years.
- •Both sexes.
- •Patients diagnosed with SLE who fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria and matched controls.
排除标准
- •Co-existing chronic inflammatory or autoimmune diseases.
- •Age <18 years
- •Malignancy.
- •Pregnancy or lactation.
- •Chronic liver or renal insufficiency.
- •Malignant hematologic diseases.
- •Active hepatitis.
- •Acute infection within the previous four weeks
研究组 & 干预措施
Healthy controls:Age and sex-matched healthy individuals without any history of autoimmune diseases
干预措施: Albumin to globulin ratio and prognostic nutritional index model (Diagnostic Test)
Active SLE group:patients with active (SLE), fulfilling the ACR/EULAR classification criteria,
干预措施: Albumin to globulin ratio and prognostic nutritional index model (Diagnostic Test)
结局指标
主要结局
assess the utility of the albumin-to-globulin ratio (AGR) as reliable, non-invasive biomarker for predicting disease activity in patients with systemic lupus erythematosus (SLE).
时间窗: From 6 month to one year
次要结局
未报告次要终点
研究者
Hala Abdellatif Hamed
Resident of Physical Medicine, Rheumatology and Rehabilitation Department
Sohag University