Study to determine the influence of incision position on physiological and biochemical changes in tissue skin flaps after surgery for total knee replacement.
- Conditions
- OsteoarthritisMusculoskeletal Diseases
- Registration Number
- ISRCTN06592799
- Lead Sponsor
- HS Greater Glasgow and Clyde (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
1. Patients who require total knee replacement
2. Sex - Male or Female subjects
3. Age ? Minimum age of 18, no upper age limit
4. Subjects, who in the opinion of the Investigator are able to understand this investigation, co operate with the investigation procedures
5. Subjects who are able to give voluntary, written informed consent to participate in this investigation and from whom consent has been obtained
1. Patients who require revision knee surgery
2. Patients who have had previous surgery or trauma to the knee that may influence the blood supply to the skin covering the knee
3. Patients who are clinically obese
4. Patients who have vascular disease
5. Subjects who are currently involved in any injury litigation claims
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To determine the influence of incision position for total knee replacement on cutaneous blood flow<br>This measure at baseline (pre-operatively) and then at 24 hours (Day 1) and 72 hours (Day 3) post-operatively. Blood flow was measured using Laser Speckle Contrast Blood Perfusion Imager, Moor FLPI (Moor Instruments, Axminster, UK).
- Secondary Outcome Measures
Name Time Method 1. To determine the influence of incision position for total knee replacement on metabolic accumulations in the interstitial fluid of the resultant skin flap<br>2. To determine the effects of incision position on nerve innervation of the overlying skin flap during total knee replacement and patient perception of post operative pain<br>3. To determine rates of early sites specific infection for both midline and medial parapatellar incisions