Identification of a single parainfluenza-specific lymphocyte in tonsillar focal disease and verification of its involvement in the pathogenesis with single-cell RNA-sequencing

Not Applicable

Recruiting

• Conditions: IgA nephropathy, palmoplantar pustulosis, sleep apnea syndrome, tonsillar hypertrophy; tonsillar focal disease, palatotonsillectomy, lymphocyte, Haemophilus Parainfluenzae; D005922, D011565, D020181, D014066

• Registration Number: JPRN-jRCT1050220136
• Lead Sponsor: Kaneko Fumie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-12-19
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

(1)Patients who have indicated for palatotonsillectomy for the treatment of IgA nephropathy as tonsillar focal disease.
(2) Patients who have indicated for palatotonsillectomy for the treatment of palmoplantar pustulosis as tonsillar focal disease.
(3) Patients who have indicated for palatotonsillectomy with sleep apnea syndrome or enlarged palatine tonsils to relieve upper airway stenosis.

Exclusion Criteria

(1) Patients with enlarged tonsils due to neoplastic lesions such as malignant tumors (tonsil cancer, malignant lymphoma, etc.) and benign tumors (papilloma of the pharynx), or suspected patients
(2) Patients undergoing emergency palatotonsillectomy due to severe bacterial infection such as peritonsillar abscess and recurrent tonsillitis
(3) Other patients deemed inappropriate to participate in the study.

Study & Design

• Study Type: Observational
• Study Design: Not specified