Enhancement of the sensitivity of a whole-blood interferon gamma assay (Quantiferon TB Gold) for diagnosis of latent tuberculosis infectio

Completed

• Conditions: latent tuberculosis infection; 10028440

• Registration Number: NL-OMON37917
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Patients with an inflammatory disease who are or have been previously screened for latent tuberculosis infection (with or without current treatment with a TNF antagonist)
negative controls: healthy uninfected individuals
positive controls: known latent TB infection or previously treated TB patients

Exclusion Criteria

none

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In vitro production of interferon gamma (alternatively IP-10 could be used) in<br /><br>a whole-blood test with specific TB antigens, in which test conditions will be<br /><br>varied in order to enhance the sensitivity </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>