Developing Mathematical Methods for Non-invasive Reconstruction of Electrical Heart Activity From Body-surface Electrocardiograms and a CT-based Torso-heart Geometry
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Diseases
- Sponsor
- Maastricht University Medical Center
- Enrollment
- 65
- Locations
- 1
- Primary Endpoint
- Epicardial potentials
- Last Updated
- 4 years ago
Overview
Brief Summary
Non-invasive reconstruction of electrical heart activity can yield important scientific and clinical insights in cardiac rhythm disorders. In this study, The investigators aim at developing methods for reconstructing electrical heart activity non-invasively, and to use these methods to investigate cardiac rhythm disorders to answer clinical and scientific questions.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 years or older
- •able to provide informed consent
- •Conditions that might alter electrical conduction properties in the heart, including (but not limited to): Brugada syndrome (BS), Arrhythmogenic right ventricular cardiomyopathy (ARVC), demonstrated ventricular arrhythmias (resuscitation, (non)sustained ventricular tachycardia, ventricular fibrillation)
- •Implanted cardiac device, such as pacemaker or implantable cardioverter defibrillator
- •Additional Inclusion Criteria for group 1 (CT group):
- •Existing medical indication for a cardiac CT scan unrelated to this research
- •There are no additional inclusion criteria for group 2 (no-CT group).
Exclusion Criteria
- •Known strong reaction against electrode attachment
Outcomes
Primary Outcomes
Epicardial potentials
Time Frame: Day one, direct measurement
Primary outcome data include reconstructed electrical heart activity such as: - epicardial potentials (units: millivolts \[mV\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: - Reconstructed epicardial potentials (mV) will be compared to selected invasive epicardial potentials (mV) obtained from catheter-based recordings or pacemaker-based recordings available as clinical data
Epicardial electrograms
Time Frame: Day one, direct measurement
Primary outcome data include reconstructed electrical heart activity such as: - epicardial electrograms (units: millivolts \[mV\] over milliseconds \[ms\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: - Reconstructed electrograms (mV) will be compared to selected invasive epicardial electrograms (mV) obtained from catheter-based recordings or pacemaker-based recordings available as clinical data
Epicardial activation and recovery sequences
Time Frame: Day one, direct measurement
Primary outcome data include reconstructed electrical heart activity such as: - epicardial activation and recovery isochrones (units: milliseconds \[ms\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: - Reconstructed activation and recovery sequences (ms) will be compared to recorded catheter-based sequences from clinical data (ms).
Secondary Outcomes
- Disease-specific differences in primary outcome measures(Day one, direct measurement)