Developing Mathematical Methods for Non-invasive Reconstruction of Electrical Heart Activity From Body-surface Electrocardiograms and a CT-based Torso-heart Geometry
试验速览
- 阶段
- 不适用
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- Epicardial potentials
研究概览
简要总结
Non-invasive reconstruction of electrical heart activity can yield important scientific and clinical insights in cardiac rhythm disorders. In this study, The investigators aim at developing methods for reconstructing electrical heart activity non-invasively, and to use these methods to investigate cardiac rhythm disorders to answer clinical and scientific questions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overall Inclusion Criteria:
- •18 years or older
- •able to provide informed consent
- •Conditions that might alter electrical conduction properties in the heart, including (but not limited to): Brugada syndrome (BS), Arrhythmogenic right ventricular cardiomyopathy (ARVC), demonstrated ventricular arrhythmias (resuscitation, (non)sustained ventricular tachycardia, ventricular fibrillation)
- •Implanted cardiac device, such as pacemaker or implantable cardioverter defibrillator
- •Additional Inclusion Criteria for group 1 (CT group):
- •Existing medical indication for a cardiac CT scan unrelated to this research
- •There are no additional inclusion criteria for group 2 (no-CT group).
排除标准
- •Known strong reaction against electrode attachment
研究组 & 干预措施
BSPM-only group
Participants will only receive body-surface potential mapping (BSPM) with an extensive electrode set (256 electrodes).
干预措施: Body-surface potential mapping (Device)
CT+BSPM group
Participants will receive body-surface potential measurements (BSPM) and a CT scan. These data will allow for non-invasive reconstruction of electrical potentials at the heart surface.
干预措施: Computed tomography (CT) scan (Radiation)
CT+BSPM group
Participants will receive body-surface potential measurements (BSPM) and a CT scan. These data will allow for non-invasive reconstruction of electrical potentials at the heart surface.
干预措施: Body-surface potential mapping (Device)
结局指标
主要结局
Epicardial potentials
时间窗: Day one, direct measurement
Primary outcome data include reconstructed electrical heart activity such as: - epicardial potentials (units: millivolts \[mV\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: - Reconstructed epicardial potentials (mV) will be compared to selected invasive epicardial potentials (mV) obtained from catheter-based recordings or pacemaker-based recordings available as clinical data
Epicardial electrograms
时间窗: Day one, direct measurement
Primary outcome data include reconstructed electrical heart activity such as: - epicardial electrograms (units: millivolts \[mV\] over milliseconds \[ms\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: - Reconstructed electrograms (mV) will be compared to selected invasive epicardial electrograms (mV) obtained from catheter-based recordings or pacemaker-based recordings available as clinical data
Epicardial activation and recovery sequences
时间窗: Day one, direct measurement
Primary outcome data include reconstructed electrical heart activity such as: - epicardial activation and recovery isochrones (units: milliseconds \[ms\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: - Reconstructed activation and recovery sequences (ms) will be compared to recorded catheter-based sequences from clinical data (ms).
次要结局
- Disease-specific differences in primary outcome measures(Day one, direct measurement)