Coronary Hemodynamics by Coronary Angiography
- Conditions
- Coronary Artery Disease
- Interventions
- Drug: Hyperemic stimuli
- Registration Number
- NCT04646278
- Lead Sponsor
- KangWon National University Hospital
- Brief Summary
Study for developing techniques to evaluate coronary artery hemodynamic profiles by conventional angiography without more dedicated measuring devices.
- Detailed Description
\* Methods: Compare TIMI frame count, coronary clearance frame count in baseline/hyperemic coronary angiography with FFR, CFR, IMR and derive correlation, receiver-operating characteristic curve to find new tools estimating coronary hemodynamics by conventional angiography only.
A TIMI frame count is measured by counting the angiographic image cine frames during a head of radiocontrast column runs from the entry of left anterior descending artery (LAD) to the distal end.
A coronary clearance frame count is measured by counting the angiographic image cine frames during a tail of radiocontrast column runs from the entry of LAD to the distal end.
Baseline angiography is performed without any stimulation and hyperemic angiography is performed after intracoronary injection of adenosine 300ug or nicorandiol 2mg.
Inclusion criteria
* Patient who underwent physiologic study using a pressure wire for intermediate coronary lesion after coronary angiography
Exclusion criteria
* ST elevation myocardial infarction
* Cardiogenic shock
* Congestive heart failure with pulmonary edema
* LVEF \< 30%
* Previous history of coronary revascularization
* Chronic total occlusion
* 3 vessel disease
* Target lesion at distal segments or branches
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Hyperemic stimuli Hyperemic stimuli Hyperemic stimuli of coronary flow by adenosine or nicorandil injection
- Primary Outcome Measures
Name Time Method Coronary Clearance Frame Count Imediately after the procedure frame count between the beginning and end of contrast column tail
TIMI frame count Imediately after the procedure frame count between the beginning and end of contrast column head
Index of microcirculatory resistance During the procedure derived from distal coronary pressure by transit time
- Secondary Outcome Measures
Name Time Method Fractional flow reserve During the procedure measured by pressure wire
Coronary flow reserve During the procedure measured by pressure wire by thermodilution technique
Trial Locations
- Locations (1)
Kangwon National University Hospital
🇰🇷Chuncheon, Gangwon-do, Korea, Republic of