squalene and COVID-19
Phase 3
Recruiting
- Conditions
- Covid-19 disease.covid-19 diseaseU07.1
- Registration Number
- IRCT20200927048848N2
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Patients with Covid-19 who have been confirmed by CT scan
The patient has been admitted to the Intensive Care Unit (ICU) due to severe or critical condition
Exclusion Criteria
Known history of myocardial ischemia and heart failure and advanced COPD
No consent of the patient or with the drug injection.
Any mental disability that prevents effective communication.
Existence of any physical disability that prevents one from performing daily activities independently. (Physical disability leads to disability before COVID-19 disease)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Response to treatment criteria including respiratory rate, SPO2 in room air , presence or absence of fever for 2 days, oral tolerance, clinical judgment of the physician. Timepoint: Response to treatment will be evaluated daily, 24 hours after the first injection. Method of measurement: The number of breaths per minute will be counted by the evaluator, the blood oxygen level will be checked with a pulse oximeter, the fever will be measured sublingually using a mercury thermometer. Oral tolerance will also be recorded by evaluators.
- Secondary Outcome Measures
Name Time Method Response to treatment criteria include respiratory rate less than 24 per minute, SPO2 in room air >= 93%, absence of fever for 2 days, oral tolerance, clinical judgment of the physician. Timepoint: Response to treatment will be assessed daily, 24 hours after the first injection. Method of measurement: The number of breaths per minute will be counted by the evaluator, the blood oxygen level will be checked with a pulse oximeter, the fever will be measured sublingually using a mercury thermometer. Oral tolerance will also be recorded by evaluators.