Effectiveness and Neuropsychological Predictors of Guided Self-Help for Obsessive-Compulsive Disorder (OCD)

Not Applicable

Completed

• Conditions: Obsessive-Compulsive Disorder
• Interventions: Behavioral: "OCFighter"

• Registration Number: NCT01659125
• Lead Sponsor: Hartford Hospital

Brief Summary

The primary aim of this study is to learn about who is most likely to benefit from guided self-help (GSH) for obsessive-compulsive disorder (OCD).

Detailed Description

40 Participants with OCD will be recruited. They will be given access to OC Fighter, an internet OCD treatment program. During the 17 week program, participants will meet with a therapist 9 times. Assessments will occur at pretreatment, post-treatment, 3-month follow up and 6-month follow up.

Study Timeline

• Study Start: 2012-08
• Study First Submitted: 2012-08-03
• Study First Submitted QC: 2012-08-06
• Study First Posted: 2012-08-07
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Results First Submitted: 2015-04-08
• Status Verified: 2015-12
• Results First Submitted QC: 2015-12-02
• Last Update Submitted: 2015-12-02
• Results First Posted: 2016-01-07
• Last Update Posted: 2016-01-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Principal or co-principal diagnosis of OCD
• Clinical global impression score greater than or equal to 4
• Y-BOCS score great than or equal to 8
• Fluency in English
• Capacity to understand the nature of the study and willingness to sign informed consent form

Exclusion Criteria

• Active manic episode, psychosis, pervasive developmental disorder, mental retardation
• Concurrent OCD psychotherapy
• Current threat of harm to self or others
• Previous adequate trial of therapist-administered or self-administered exposure and response prevention for OCD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
OCFighter	"OCFighter"	OCFighter

Primary Outcome Measures

Name	Time	Method
Change in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS)	Baseline (pretreatment), 17-weeks (posttreatment), and 6 month-follow-up	The Y-BOCS is a semi-structured interview that assesses severity of obsessions and compulsions. The total score is reported here and ranges from 0 to 40 with higher scores indicating more severe OCD symptoms.
Responder Status	Week 17 (post-treatment) and 6-month follow-up	Participants who experienced a clinically significant change in Y-BOCS score defined as posttreatment YBOCS score that (a) has decreased by a reliable level (at least 1.96 times the standard deviation of that measure, taking into account the reliability of the measure itself; in this case, a decrease of 5 points or more), and (b) is within the nonclinical range of scores (in this case, a score of 13 or below).

Trial Locations

Locations (1)

Hartford Hospital; 🇺🇸 Hartford, Connecticut, United States