ACTRN12619000080123
Completed
未知
Characterising the prothrombotic changes associated with transcatheter aortic valve implantation: the key to promoting the rational use of anti-thrombotic prophylaxis and minimizing devastating thromboembolic and bleeding complications
St. Andrew's War Memorial Hospital0 sites40 target enrollmentJanuary 21, 2019
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- transcatheter aortic valve implantation
- Sponsor
- St. Andrew's War Memorial Hospital
- Enrollment
- 40
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\) Informed consent for participation;
- •2\) Either: i) severe aortic stenosis (aortic valve area \<0\.8cm2, mean aortic valve gradient \>40mmHg or peak jet velocity \>4m/s); AND planned management with either a TF\-TAVI or isolated AVR; OR, ii) Non\-ST elevation myocardial infarction (new ischaemic ECG criteria, troponin \> upper limit of normal, clinical symptoms); AND planned management with elective PCI; 3\) Stable haemoglobin \> 100g/l; 4\) Non\-emergency procedure; 5\) Preserved ejection fraction (\>50%).
Exclusion Criteria
- •1\) Lack of capacity to consent for him or herself; 2\) Medications known to: i) interact with coagulation assays; or ii) have a known or suspected prothrombotic or coagulopathic action that cannot be corrected for by the analysers used for point of care coagulation testing; 3\) Known or suspected bleeding or clotting disorders; 4\) Severe liver, renal, respiratory or psychiatric disease (including substance abuse); 5\) Enrolled in another study with a non\-standard treatment intervention.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Not yet recruiting
Not Applicable
To establish whether platelet morphology or functions are altered in patients of Retinal Vein OcclusioCTRI/2024/08/071831IMS BH
Recruiting
Not Applicable
Dynamic changes in clot formation using Thromboelastometry after reinfusion of unwashed cell salvaged whole blood in total hip arthroplasty: a pilot studyACTRN12612000691842Astra Tech AB25
Completed
Not Applicable
Assesment of changes of coagulatory/ fibrinolysis factors after major hepatectomy or pancreatoduodenectomyBiliary tract carcinoma Hepatocellular carcinoma Pancreas cancerJPRN-UMIN000006642agoya university Graduate School of Medicine80
Active, not recruiting
Phase 1
Modulation of Clot Structure and Platelet Function by Aspirin in Individuals with Diabetes: the role of aspirin dose and Glycaemic control - Aspirin in DiabetesType 1 Diabetes MellitusEUCTR2008-007875-26-GBniversity of Leeds96
Active, not recruiting
Phase 1
DISTINCT: inDividual, targeted thrombosIS prophylaxis versus the standard ‘one size fits all’ approach in patients undergoing Total hIp or total kNee replaCemenT: a national, multicenter, randomized, multi-arm, open-label trialVenous thromboembolismTherapeutic area: Diseases [C] - Cardiovascular Diseases [C14]CTIS2023-510186-98-00Academisch Ziekenhuis Leiden10,078