Abdominal Ultrasound With Doppler and Peripheral Hemogram in Assesment Inflammatory Bowel Disease

Completed

• Conditions: Inflammatory Bowel Diseases
• Interventions: Drug: Infliximab

• Registration Number: NCT03445624
• Lead Sponsor: Assiut University

Brief Summary

assessment of inflammatory bowel disease patients in activity and remission by abdominal ultrasound examine non-invasive and in physiological condition by measuring the colon wall thickness in diagnosis and follow up the patient also including extra intestinal features such as the splanchnic vessels,mesentery and lymph nodes . Doppler u.s can evaluate bowel wall vascularity In activity and remission . peripheral hemogram in relationship to activity inflammatory bowel disease asses anemia ,increase monocyte and decrease mean platelet volume( MPV) . also,the investigator will evaluate the outcome of different lines of treatment traditional and biologic therapy (response to treatment,times of activity and complications)

Detailed Description

the participants will follow up the patient for 1 year in the first visit

All patients in this study will be subjected to:

1. Detailed history.

2. Careful physical examination

3. laboratory investigation

1. complete blood picture.

2. liver function

3. kidney function

4. Iron profile(serum iron ,serum ferritin

5. ESR (erythrocyte sedimentation rate )

g-CRP (C reactive protein) f-LDH (lactate dehydrogenase)

4. Abdominal us(the colon wall thickness,lymph nodes,mass,other organs)

5. Doppler us (mesenteric vessels)

6. colonoscopy after 1 year of treatment follow up every 3 months by abdominal US and peripheral hemogram and last visit after 1 year colonoscopy and biopsy for assessment response to treatment

Study Timeline

• Study First Submitted: 2018-01-09
• Study First Submitted QC: 2018-02-20
• Study First Posted: 2018-02-26
• Study Start: 2018-07-01
• Status Verified: 2020-07
• Primary Completion: 2021-02-01
• Study Completion: 2021-10-01
• Last Update Submitted: 2023-08-26
• Last Update Posted: 2023-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patient on traditional therapy	Infliximab	Drug: steroid,5ASA , immuran for assesment the outcome of therapy in inflammatory bowel disease steroid(40- 60mg tablet),5ASA(pentasa 3-4gm tablet),azathioprin (immuran 100 mg tablet)
patient on infliximab	Infliximab	drug : infliximab (5mglkg intravenous)for the first dose,the second dose after 2 weeks the third dose after 6 weeks then every 2 months

Primary Outcome Measures

Name	Time	Method
the role abdominal ultrasound in assessment inflammatory bowel disease	2 year	measure the thickness of the colon by abdominal ultrasound and doppler mesenteric vessels .more than 4ml detect activity doppler mesenteric highly vascularity in activity

Trial Locations

Locations (1)

Hyam Fathy; 🇪🇬 Assiut, Egypt