Effect of Substitution of Methadone by Buprenorphine on Gonadal Hormones and Seme
- Conditions
- Male infertility in opioid substitution treatment.Male infertility
- Registration Number
- IRCT2016011626040N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 40
men between 18 to 50 y/o; at least 6 months on Opioid Substitution Treatment & 3 months from last illegal opioid use; daily Methadone dose less than 60 mg/d; certification of therapist physician on stability & readiness of client for shifting from methadone to buprenorphine; diagnosis of methadone as the most important factor for undesirable hormonal & seminal analysis; written & signed informed consent form.
Exclusion criteria: evidence or signs of laps & relapse in buprenorphine treatment even with appropriate dose; absence from treatment more than 2 consecutive or 3 undulant weeks; absence from screening opioid urine test more than 2 consecutive or 3 undulant sessions; absence from hormonal & seminal analysis more than 2 weeks after appointed time; intolerance of methadone dose reduction for shifting to buprenorphine; intolerance of buprenorphine side effects.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method