Study of Resistance Strengthening Versus Ambulation Post-Liver Transplant

Not Applicable

Completed

• Conditions: Liver Transplantation; Resistance Training; Activities of Daily Living
• Interventions: Other: Resistance Strengthening Exercise Program

• Registration Number: NCT01216722
• Lead Sponsor: University of Miami

Brief Summary

Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.

Detailed Description

Individuals post liver transplantation are significantly muscle wasted due to chronic liver disease. Current Usual care only involves progressive ambulation. Resistance exercise targeted at the lower extremities are anticipated to increase muscle strength in the muscles that extend the hip, extend the knee, and plantar flex the ankle more than seen with the usual care ambulation. The anticipated increases in strength should improve functional performance of activities such as standing from a chair, walking, and climbing stairs. The improvement in strength and functional performance should improve an individuals quality of life.

Study Timeline

• Study Start: 2007-10
• Primary Completion: 2009-10
• Status Verified: 2010-07
• Study Completion: 2010-07
• Study First Submitted: 2010-10-06
• Study First Submitted QC: 2010-10-06
• Last Update Submitted: 2010-10-06
• Study First Posted: 2010-10-07
• Last Update Posted: 2010-10-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• Undergone Liver Transplantation a minimum of 6 weeks and a maximum of 12 weeks prior to enrollment
• Ambulatory without physical assistance, but permitted to use a cane or walker

Exclusion Criteria

• Diagnosis of Hepatocellular Carcinoma
• Significant Cardiopulmonary disease
• Neurological / Neuromuscular Disorder including cerebral vascular accident (CVA), Parkinson's Disease, Alzheimer's Disease, Dementia unrelated to Hepatic Encephalopathy, dystonia, multiple sclerosis, and polio.
• Blindness
• Inability to comprehend the English or Spanish Language

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resistance Strengthening	Resistance Strengthening Exercise Program	Body weight antigravity positioning and elastic resistance bands are used to provide resistance for strengthening in supine, sitting, and standing in subjects post liver transplant.

Primary Outcome Measures

Name	Time	Method
Six Minute Walk Test	12 weeks
30-Second Chair-Stand Test	12 weeks
Bridge Test	12 weeks
Heel Rise Test	12 weeks

Secondary Outcome Measures

Name	Time	Method
Short Form (SF-36) Questionnaire	12 weeks
Chronic Liver Disease Questionnaire (CLDQ)	12 weeks

Trial Locations

Locations (1)

University of Miami Department of Physical Therapy; 🇺🇸 Coral Gables, Florida, United States