Comparison of Targeted Lower Extremity Strengthening and Usual Care Progressive Ambulation in Subjects Post Liver Transplant: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 2
- 主要终点
- Bridge Test
研究概览
简要总结
Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.
详细描述
Individuals post liver transplantation are significantly muscle wasted due to chronic liver disease. Current Usual care only involves progressive ambulation. Resistance exercise targeted at the lower extremities are anticipated to increase muscle strength in the muscles that extend the hip, extend the knee, and plantar flex the ankle more than seen with the usual care ambulation. The anticipated increases in strength should improve functional performance of activities such as standing from a chair, walking, and climbing stairs. The improvement in strength and functional performance should improve an individuals quality of life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergone Liver Transplantation a minimum of 6 weeks and a maximum of 12 weeks prior to enrollment
- •Ambulatory without physical assistance, but permitted to use a cane or walker
排除标准
- •Diagnosis of Hepatocellular Carcinoma
- •Significant Cardiopulmonary disease
- •Neurological / Neuromuscular Disorder including cerebral vascular accident (CVA), Parkinson's Disease, Alzheimer's Disease, Dementia unrelated to Hepatic Encephalopathy, dystonia, multiple sclerosis, and polio.
- •Blindness
- •Inability to comprehend the English or Spanish Language
结局指标
主要结局
Bridge Test
时间窗: 12 weeks
Six Minute Walk Test
时间窗: 12 weeks
30-Second Chair-Stand Test
时间窗: 12 weeks
Heel Rise Test
时间窗: 12 weeks
次要结局
- Short Form (SF-36) Questionnaire(12 weeks)
- Chronic Liver Disease Questionnaire (CLDQ)(12 weeks)