Comparison of Targeted Lower Extremity Strengthening and Usual Care Progressive Ambulation in Subjects Post Liver Transplant: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Liver Transplantation
- Sponsor
- University of Miami
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Bridge Test
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.
Detailed Description
Individuals post liver transplantation are significantly muscle wasted due to chronic liver disease. Current Usual care only involves progressive ambulation. Resistance exercise targeted at the lower extremities are anticipated to increase muscle strength in the muscles that extend the hip, extend the knee, and plantar flex the ankle more than seen with the usual care ambulation. The anticipated increases in strength should improve functional performance of activities such as standing from a chair, walking, and climbing stairs. The improvement in strength and functional performance should improve an individuals quality of life.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Undergone Liver Transplantation a minimum of 6 weeks and a maximum of 12 weeks prior to enrollment
- •Ambulatory without physical assistance, but permitted to use a cane or walker
Exclusion Criteria
- •Diagnosis of Hepatocellular Carcinoma
- •Significant Cardiopulmonary disease
- •Neurological / Neuromuscular Disorder including cerebral vascular accident (CVA), Parkinson's Disease, Alzheimer's Disease, Dementia unrelated to Hepatic Encephalopathy, dystonia, multiple sclerosis, and polio.
- •Blindness
- •Inability to comprehend the English or Spanish Language
Outcomes
Primary Outcomes
Bridge Test
Time Frame: 12 weeks
Six Minute Walk Test
Time Frame: 12 weeks
30-Second Chair-Stand Test
Time Frame: 12 weeks
Heel Rise Test
Time Frame: 12 weeks
Secondary Outcomes
- Short Form (SF-36) Questionnaire(12 weeks)
- Chronic Liver Disease Questionnaire (CLDQ)(12 weeks)