Establishment and Implementation of Nebulised High Volumes of Hypertonic Saline in Cystic Fibrosis Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cystic Fibrosis
- Sponsor
- Haukeland University Hospital
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Tolerance and safety of high volumes of inhaled hypertonic saline measured by forced expiratory volume at one second
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Background Nebulised hypertonic saline (HS) is an established basic airway clearance treatment in Cystic Fibrosis (CF). However, there is scarce evidence regarding the practical implementation and administration of different HS volumes, including physiotherapy and aspects of breathing pattern.
The aim of the study was to implement standardised and age-adjusted nebulised volumes of hypertonic saline in cystic fibrosis patients, included in physiotherapy and lung drainage techniques.
Detailed Description
Aims: To establish a safe, efficient routine for implementation of HS in daily treatment and to investigate the efficiency and tolerance of high volumes of HS integrated with chest physiotherapy. HS was given twice daily with volumes of 4,5 ml in children aged 0-5 years, 6 ml at age 6-16 years and 9 ml at age \> 16 years. The protocol included guidance of standardized breathing pattern, upright and sideways positioning and voluntary cough.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Cystic fibrosis
Exclusion Criteria
- •Non-adherence
Outcomes
Primary Outcomes
Tolerance and safety of high volumes of inhaled hypertonic saline measured by forced expiratory volume at one second
Time Frame: 24 months
Secondary Outcomes
- Implementation of nebulised high volumes of hypertonic saline in cystic fibrosis patients(24 months)