Comparison of SUV Using SPECT/CT Between Grave's Disease Patients and Normal Humans
- Conditions
- TomographySingle-PhotonHyperthyroidismEmission-Computed
- Registration Number
- NCT02772705
- Lead Sponsor
- West China Hospital
- Brief Summary
The purpose of this study is to find out the capacity of standardized uptake value (SUV) using single-photo emission computed tomography and computed tomography (SPECT/CT) in diagnosing Grave's Disease (hyperthyroidism).
- Detailed Description
Traditionally it is considered that only positron emission tomography(PET) has the ability to obtain standardized uptake value（SUV）while single-photo emission computed tomography(SPECT) does not have. Recently with the developing of technology, the ability of SPECT has been extended.
On the other hand, thyroid imaging by SPECT can only play an auxiliary role in hyperthyroidism diagnosis mainly since it is regarded as nonquantitative. So the investigators design this study to search the capacity and accuracy of SUV provided by SPECT and CT(CT is used for reconstruction algorithm) in diagnosing GD.
This is a multiple-center study containing nine groups in China that use GE Discovery NM/CT, an advanced equipment. Thus, the data can be more accurate and more available.
And this is a perspective clinical trial, taking about eight months. The investigators plan to evaluate at least 50 Grave's Disease(GD) patients and 50 normal humans as contrast in all.
Every GD patient must have been diagnosed and the results of thyroid function tests(such as TSH,FT3,FT4） must be available. If necessary, the patient's rate of iodine uptake should also be known before he/she being included in this study. As for normal people, the results of thyroid function tests should be within the range of normal value.
The data of each participant will be gathered and stored. And the data processing will be done with the help of GE staff, using the software Q.Metrix to get the value of SUVmean, SUVmax. Finally T test will be used in comparison of the differences.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- certainly diagnosed with GD
- no treatment
- sign a informed consent
- Inflammatory Hyperthyroidism
- Secondary Hyperthyroidism (since of medicine, thyrotrophs neoplasms and etc)
- Can not finish the check of SPECT/CT
- Refuse to sign a informed consent
For Group of Normal Humans:
Inclusion Criteria:
- without GD
- Adult
- sign a reformed consent
Exclusion Criteria:
- Without normal values of TSH, FT3, FT4
- Can not finish the check of SPECT/CT
- Failed to sign a reformed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The SUV values of GD patients and normal humans provided by Q.Metrix a single point in time, at subject enrollment The data of thyroid fusion imaging will be processed by the software, Q.Metrix, which can get the accurate SUV by compensating for photon absorption within the body, removing scattered radiation and etc.
The thyroid imaging of GD patients and normal humans by SPECT/CT a single point in time, at subject enrollment For GD patients and normal healthy volunteers, we will get the data of thyroid fusion imaging by giving them a SPECT/CT check at subject enrollment.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (9)
Hebei General Hospital
🇨🇳Shijiazhuang, Hebei, China
Beijing Tongren Hospital
🇨🇳Beijing, Beijing, China
Guangzhou Panyu Central Hospital
🇨🇳Guangzhou, Guangdong, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, Henan, China
Zhejiang Cancer Hospital
🇨🇳Hangzhou, Zhejiang, China
The People's Hospital of Inner Mongolia Autonomous Region
🇨🇳Hohhot, Inner Mongolia, China
Fourth Military Medical Universit
🇨🇳Xi'an, Shanxi, China
West China Hospital
🇨🇳Chengdu, Sichuan, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China