TCTR20170629004已完成3 期
The Efficiency of Furosemide, Salt tablet and Fluid restriction for Long-term Treatment of Patients with Syndrome of Inappropriate Antidiuresis (SIAD): A Double-blinded Randomized Controlled Trial
Renal Division, Department of Internal Medicine, Chiang Mai University0 个研究点目标入组 90 人开始时间: 2017年6月29日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 0 N/A (No limit)（—）
- 性别
- All
入选标准
- •- Age of more than 18 years old
- •- Serum sodium ≤130 mmol/L
- •- Chronic hyponatremia (>48 hour after onset or unknown onset)
- •- Diagnosis of SIAD, all following criterion must be met:
- •- Effective serum osmolality<275 mOsm/kg
- •- Urine osmolality >100 mOsm/kg H2O
- •- Clinical euvolemia
- •- Urine sodium concentration >30 mmol/L with normal dietary salt and water intake
- •- Absence of hypothyroidism (thyroid-stimulating hormone <10 mIU/mL), glucocorticoid deficiency (unstimulated or stimulated cortisol level 10 ug/dL or) and significant renal insufficiency (define as serum creatinine > 1.2 or diagnosed as acute kidney injury)
排除标准
- •- Clinical overt hypovolemia or hypervolemia
- •- Decompensated liver cirrhosis, symptomatic heart failure, and nephrotic syndrome
- •- Hemodynamic unstable
- •- Current using investigational agents (salt tablet or furosemide), other diuretics and steroids
- •- Severe symptomatic hyponatremia at diagnosis (defined as vomiting, cardiorespiratory distress, abnormal and deep somnolence, seizures, and coma (which define as Glasgow Coma Scale 8)
- •- Hyperglycemia enough to interfere with assessment of serum sodium, defined as random plasma glucose >300 mg/dL at the time of diagnosis
- •- Receiving renal replacement therapy
- •- Post kidney transplant status
- •- Furosemide allergy
- •- Contraindicated for eating or feeding via enteral route
研究者
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