Comparing curcumin mediated photodynamic therapy and topical corticosteroid in tratment of oral OLP
- Conditions
- oral lichen planus.Lichen planus
- Registration Number
- IRCT20221016056202N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 14
Clinical diagnosis of OLP by 2 oral medicine specialists
Presence of bilateral errosive symptomatic lesions
Patients willing to actively participate in the study
Patients that are capable of performing the exact instructions of the treatment protocol.
Age < 18 years
Pregnancy or lactation
Uncontrolled systemic diseases (hepatopathies, coagulopathies,auto immune or haematological diseases)
History of allergic reactions to the active ingredient (curcumin) used in the clinical trial
Presence of histological signs of dysplasia in the biopsy specimen
Evidence of lichenoid lesions due to specific causes (dental materials, use of drugs inducing lichenoid reactions such as hypertensive or diabetic medications, etc.)
Smokers or heavy drinkers of alcohol.
Diabetic patients
Patients with photosensivity
Lichenoid reaction
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: visual analogue scale.;Size of lesion. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: Digital caliper.;Clinical manifestations of inflammation. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: Thongprasom sign scoring.;Clinical Efficacy of treatment. Timepoint: days 0 and 7 and 14 and 28 and 56. Method of measurement: REU.
- Secondary Outcome Measures
Name Time Method Allergy to curcumin. Timepoint: days 1 and 3 and 5. Method of measurement: Observe the side effects of increased sensitivity.