NCT00967642TerminatedNot Applicable
Intravenous Insulin for 24 Hours in Patients With Diabetes Mellitus Submitted to Percutaneous Coronary Intervention With Stent: Effects Upon Oxidative Stress and Inflammatory Markers
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 70
- Primary Endpoint
- Reintervention, Myocardial Infarction, Cardiovascular Death
Study Overview
Brief Summary
The purpose of this study is to evaluate the effects of intravenous insulin/24 hours to normalize glycemia upon markers of oxidative stress (protein oxidation and total antioxidant defense) and inflammation (C-reactive protein (CRP) and sCD40L) in diabetic patients submitted to PCI with stent.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with Diabetes Mellitus submitted to Percutaneous Coronary Intervention with Stent bare metal
- •Age: 18-80 years old
Exclusion Criteria
- •Restenosis
- •Drug elution stent
- •Acute coronary syndrome at last 30 days
- •Use anti inflammatory, antibiotic, vitamin E
- •Inflammatory disease or oncologic
Arms & Interventions
Intravenous Insulin
Other
intravenous insulin/24h guided by glycemia (Optium, Abbott) evaluated hourly, targeting values lower than 110 mg/dl
Intervention: Intravenous Insulin (Drug)
Outcomes
Primary Outcomes
Reintervention, Myocardial Infarction, Cardiovascular Death
Time Frame: 6 months
Secondary Outcomes
No secondary outcomes reported
Investigators
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