Peri Kasai Portoenterostomy Anchoring of the Jejunal Loop

Not Applicable

• Conditions: Biliary Atresia
• Interventions: Procedure: kasai portoenterostomy

• Registration Number: NCT04961034
• Lead Sponsor: Tanta University

Brief Summary

the study of the effect o the hanging of the jejunal loop to the peri KPE Glisson capsule on the rate of bile drainage and requirement of liver transplantation

Detailed Description

To evaluate the effect of anchoring jejunal loop to Glisson capsule of liver after completion of modified Kasai portoenterostomy (KPE) on the frequency of attacks of cholangitis and the overall incidence of native liver survival.

Methods: Retrospective study included 29 infants diagnosed as biliary atresia (BA). They were subjected to modified KPE. Two subgroups were present. Group A included 16 infants and had KPE. Group B included 13 infants and had the assumed modification. Wider dissection of fibrous portal plate was considered in both groups. After completion of KPE, the jejunal loop anchored to Glisson capsule of liver at porta hepatis in group B.

Study Timeline

• Study Start: 2015-01
• Primary Completion: 2021-06
• Study First Submitted: 2021-07-09
• Study First Submitted QC: 2021-07-09
• Study First Posted: 2021-07-14
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-26
• Last Update Posted: 2022-04-27
• Study Completion: 2023-12-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• infants with biliary atresia diagnosed and treated before 60th day of age

Exclusion Criteria

• infants older than 60 days

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
classic KPE	kasai portoenterostomy	the classic management of biliary atresia as described
modified KPE	kasai portoenterostomy	we added 2 sutures posterior, one on each side and two anterior. this will hang the jejunal loop to promote tension free anastomosis

Primary Outcome Measures

Name	Time	Method
the total number of cholangitis	two years	the total attacks of chollangitis
number of native liver survivors	two years	the decrease of the need of liver transplantation in children with biliary atresia

Secondary Outcome Measures

Name	Time	Method
early improvement of liver functions	6 months	normalization of liver function

Trial Locations

Locations (2)

Tantra Universiy; 🇪🇬 Tanta, Egypt

Tanta University; 🇪🇬 Tanta, Gharbeya, Egypt