Reversibility of Diastolic Disfunction in Septic Shock
- Conditions
- Diastolic DysfunctionSeptic Shock
- Interventions
- Diagnostic Test: Echocardiography
- Registration Number
- NCT03198611
- Lead Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
- Brief Summary
Objectives: To study the prognostic value of the evolution of diastolic function according to fluid balance in patients admitted to the ICU with a diagnosis of septic shock, in terms of mortality (ICU and hospital) and mortality at 90 days.
2.4. Secondary objectives: A) Incidence and reversibility of myocardial dysfunction (left ventricular systolic and diastolic) in septic shock.
B) Incidence and reversibility of diastolic dysfunction according to the echocardiographic criterion used.
C) Incidence and reversibility of right ventricular systolic dysfunction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 350
- Patients admitted to the ICU with diagnosis of septic shock, and stay longer than 48h
- No echocardiographic window
- Fatal prognosis with do not resuscitate orders at admission
- Previous history of Ischemic cardiomyopathy
- Valvular prosthesis
- Advanced degree of valvular disorder
- Advanced degree of pericardial effusion
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Left ventricular diastolic dysfunction Echocardiography Classification according to: * Mitral lateral annulus e' in tissue Doppler \< 10 cm/s * American society of echocardiography (ASE) criteria 2009 * ASE criteria 2016 Left ventricular systolic dysfunction Echocardiography Left ventricular ejection fraction \< 50% Normal function Echocardiography No systolic dysfunction No diastolic dysfunction No right ventricular dysfunction Right ventricular dysfunction Echocardiography Tricuspid annulus plane systolic excursion \< 17 cm
- Primary Outcome Measures
Name Time Method Mortality at 90 days 90 days Dead at 90 days
- Secondary Outcome Measures
Name Time Method ICU mortality 90 days Dead in ICU
In hospital mortality 90 days Dead in hospital
Change in incidence of diastolic dysfunction From first 24 hours of ICU admission until 48h, 72h and 7 days from admission Change in incidence of diastolic dysfunction according to the different criteria used.
Incidence of myocardial disfunction During the first 24 hours of ICU admission According to the criteria specified at groups section
Trial Locations
- Locations (4)
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital del Vall d´Hebron
🇪🇸Barcelona, Spain
Hospital Verge de la Cinta
🇪🇸Tortosa, Tarragona, Spain