NCT03198611Unknown不适用
Early Reversibility of Diastolic Disfunction as a Prognostic Factor in Septic Shock
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau4 个研究点 分布在 1 个国家目标入组 350 人开始时间: 2018年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 350
- 试验地点
- 4
- 主要终点
- Mortality at 90 days
研究概览
简要总结
Objectives: To study the prognostic value of the evolution of diastolic function according to fluid balance in patients admitted to the ICU with a diagnosis of septic shock, in terms of mortality (ICU and hospital) and mortality at 90 days.
2.4. Secondary objectives: A) Incidence and reversibility of myocardial dysfunction (left ventricular systolic and diastolic) in septic shock.
B) Incidence and reversibility of diastolic dysfunction according to the echocardiographic criterion used.
C) Incidence and reversibility of right ventricular systolic dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted to the ICU with diagnosis of septic shock, and stay longer than 48h
排除标准
- •No echocardiographic window
- •Fatal prognosis with do not resuscitate orders at admission
- •Previous history of Ischemic cardiomyopathy
- •Valvular prosthesis
- •Advanced degree of valvular disorder
- •Advanced degree of pericardial effusion
结局指标
主要结局
Mortality at 90 days
时间窗: 90 days
Dead at 90 days
次要结局
- ICU mortality(90 days)
- In hospital mortality(90 days)
- Change in incidence of diastolic dysfunction(From first 24 hours of ICU admission until 48h, 72h and 7 days from admission)
- Incidence of myocardial disfunction(During the first 24 hours of ICU admission)
研究者
研究点 (4)
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