Evaluation of Oxygenation by 100% Oxygen Via High Flow Nasal Cannula During Apnea in Adult Elective Surgical ENT Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 31
- 主要终点
- Change in arterial oxygen tension (pO2)
研究概览
简要总结
Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing it into clinical practice.
The general purpose of this project is to evaluate a new ventilation strategy during ENT-surgery based on oxygenation with high-flow nasal cannula with 100% oxygen with focus on gas exchange.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult, >18 years old
- •ENT-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery) and the anesthesia time is <40 mins.
- •Capable of understanding the study information and sign the written consent.
排除标准
- •Manifest cardiac failure or coronary disease
- •Neuromuscular disease
研究组 & 干预措施
Normoventilation
The patients will be normoventilated before anesthesia
Hyperventilation
Prior to anesthesia, the patients will hyperventilate during 2 mins or until symptoms from the central nervous system (e.g. dizziness).
干预措施: Hyperventilation (Procedure)
结局指标
主要结局
Change in arterial oxygen tension (pO2)
时间窗: From start of anaesthesia to end of apnoea oxygenation or max 30 minutes
Change in arterial pH
时间窗: From start of anaesthesia to end of apnoea oxygenation or max 30 minutes
Change in arterial carbon dioxide (pCO2)
时间窗: From start of anaesthesia to end of apnoea oxygenation or max 30 minutes
次要结局
- Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pCO2 in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation?(In the end of the apnoea period, i.e. at approximately 20 minutes)
- Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pO2 in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation?(In the end of the apnoea period, i.e. at approximately 20 minutes)
- Does the high oxygen content cause atelectasis measures as change in relation between pCO2 and end tidal carbon dioxide(Until discharge from the postoperative unit, often max 2 hours)
- Does hyperventilation prior to anaesthesia and apnoea oxygenation cause any difference in pH in the end of the apnea (i.e. at up to 30 minutes) compared to normoventilation?(In the end of the apnoea period, i.e. at approximately 20 minutes)
研究者
Malin Jonsson Fagerlund
Associate Professor/Senior Consultant
Karolinska University Hospital