Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Hippocampal Volume Measured by 3D MRI
研究概览
简要总结
This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease. Researchers are focusing on the hippocampus, a part of the brain that shrinks in people with Alzheimer's. The study will also explore other brain changes that often happen alongside hippocampal shrinkage. By analyzing these brain images, the study hopes to find ways to diagnose Alzheimer's earlier and more accurately using advanced imaging techniques.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients who underwent a brain MRI (3D T1 Bravo and Cube FLAIR sequences) between January 2018 and June
- •Diagnosis of Alzheimer's disease (for the Alzheimer group).
- •No neurological disease for control group participants.
- •Complete clinical and biological assessments available.
- •Quality imaging without motion artifacts.
排除标准
- •Incomplete clinical or radiological data.
- •Poor image quality (e.g., motion artifacts).
- •Presence of other neurodegenerative or psychiatric disorders.
结局指标
主要结局
Hippocampal Volume Measured by 3D MRI
时间窗: Retrospective analysis between January 2018 and June 2022
Objective volumetric measurement of the right and left hippocampus using 3D T1 Bravo MRI sequences, allowing quantification of hippocampal atrophy.
次要结局
未报告次要终点