Impact of inflammatory cytokines to CYP3A or OATP1B activities in rheumatoid arthritis patient using endogenous substrate. - Impact of inflammatory cytokines to CYP3A or OATP1B activities in rheumatoid arthritis patient using endogenous substrate.

37 outpatients with RA were analyzed. OATP1B115 carriers tended to have higher CP-I concentration compared to non-carriers. Plasma CP-I correlated positively with CMPF concentration, but did not correlate with IL-6 or TNF-alpha concentration. Multiple logistic regression analysis by stepwise selection identified plasma CMPF concentration and OATP1B115 allele as significant factors independently affecting plasma CP-I concentration at baseline and at the next visit, respectively.