Advanced Cardiac Imaging in Cardiac Allograft Vasculopathy

Terminated

• Conditions: Heart Transplantation

• Registration Number: NCT01927614
• Lead Sponsor: Nova Scotia Health Authority

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-8-12
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Terminated
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - > 18 years of age<br><br> - Greater than or equal to 12 months post transplant<br><br> - Able to undergo cardiac CT and cardiac MRI<br><br>Exclusion Criteria:<br><br> - Creatinine clearance less than or equal to 45ml/min per 1.73m2)<br><br> - Severe aortic stenosis<br><br> - Long-QT syndrome (corrected QT >440ms)<br><br> - AV block grade II/III<br><br> - Sick sinus syndrome<br><br> - New York Heart Association heart failure class III/IV<br><br> - Chronic obstructive pulmonary disease<br><br> - Asthma<br><br> - Atrial fibrillation<br><br> - Left ventricular ejection fraction <50%<br><br> - Presence of a pacemaker or ICD<br><br> - Presence of any metal in body

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of patients with adverse events from cardiac CT and cardiac MRI scan in heart transplant patients

Secondary Outcome Measures

Name	Time	Method
Describe CT and MRI imaging findings of established CAV;Correlation between intimal thickening by IVUS imaging at cardiac catheterization and CCT and CMR perfusion abnormalities;The association between CCT/CMR perfusion abnormalities one year post transplant and the development of angiographically apparent CAV, graft dysfunction, cardiac adverse events, and overall survival long term