Autonomic function in Alzheimer: assessment using tilt-table testing

Completed

• Conditions: Cognitive impairment; memory complaints; 10007963; 10012272; 10057166

• Registration Number: NL-OMON50891
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 75

Inclusion Criteria

Clinical diagnose of Mild Cognitive Impairment (MCI) or Alzheimer's Disease
(patient group)
Normal age-related cognitive functioning (control group)
Age 55 yrs and over

Exclusion Criteria

Bodyweight of >180 kg.
History of severe cardiovascular and neurological disorders, traumatic brain
injury, mental retardation or muscle disorders.
Use of cholinesterase inhibitors or Memantine.
Contraindicators of HUTT.
Subjects who cannot stand up actively by themselves or are immobile.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is autonomic function (cardiovascular measures of<br /><br>autonomic function derived from continuous BP and ECG signals) during HUTT in<br /><br>MCI/AD vs control. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters will be effects of changes in BP on CBF; differences in<br /><br>complexity measures in cardiovascular and cerebrovascular signals (BP, ECG,<br /><br>CBFV and NIRS) in rest and during HUTT between MCI/AD and controls.</p><br>