Emission Patterns of Respiratory Pathogens
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 55
- 主要终点
- correlation between the human aerosolization patterns and the severity of illness
研究概览
简要总结
Airborne transmission represents one of the most rapidly spreading and dangerous dissemination mechanisms for pathogens. Public health strategies to prevent and control the often explosive outbreaks associated with such pathogens are: 1) vaccination and treatment, if available, 2) isolation and barrier precautions such as face masks, and 3) decontamination of the exposed areas and surfaces. A lack of understanding how these pathogens are transmitted hampers the ability to develop effective prevention measures. This study will be used to collect preliminary data of the emission patterns of respiratory pathogens.
详细描述
Airborne transmission represents one of the most rapidly spreading and dangerous dissemination mechanisms for pathogens. The study team have been investigating bacterial and viral transmission routes and barrier precautions. In a recent clinical study, it was observed that Measles virus RNA was detected from a patient for at least up to 10 feet. In addition, the group has been studying barrier precautions (facemasks) for their ability to prevent the spread of aerosolized viruses. Finally, in a controlled lab setting the investigators have assessed the impact of environmental conditions (temperature, humidity) on pathogen transmission and the effect of UV-C light to prevent the spread of influenza. The purpose of this observational study is to describe the human aerosolization patterns of respiratory pathogens. The study team hypothesizes that the emission patterns of specific airborne pathogens varies between individual patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients >18 years of age admitted to the ED or an inpatient care unit of Wake Forest Baptist Medical Center (WFBMC)
排除标准
- •positive respiratory pathogen tests
结局指标
主要结局
correlation between the human aerosolization patterns and the severity of illness
时间窗: throughout study completion, up to 7 days
This outcome measure is to determine the correlation between the human aerosolization patterns and the severity of illness (fever, respiratory symptoms, malaise) in individual participants.
particle size distribution patterns: non-ICU setting
时间窗: throughout study completion, up to 7 days
This outcome measure will determine the particle size distribution patterns of the pathogen in the non-intensive care unit (ICU).
particle size distribution patterns: ICU
时间窗: throughout study completion, up to 7 days
This outcome measure will determine the particle size distribution patterns of the pathogen in the intensive care unit (ICU).
quantities of the pathogen: ICU
时间窗: throughout study completion, up to 7 days
This outcome measure will determine the quantities of the pathogen in the intensive care unit (ICU).
quantities of the pathogen: non-ICU setting
时间窗: throughout study completion, up to 7 days
This outcome measure will determine the quantities of the pathogen in the non-intensive care unit (ICU).
spatial model: ICU
时间窗: throughout study completion, up to 7 days
This outcome measure will establish a spatial model (1 foot vs. 3- feet vs. 8-10 feet) of airborne pathogen dispersal in the ICU.
spatial model: non-ICU setting
时间窗: throughout study completion, up to 7 days
This outcome measure will establish a spatial model (1 foot vs. 3- feet vs. 8-10 feet) of airborne pathogen dispersal in a non-ICU setting.
次要结局
未报告次要终点