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SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Phase 1
Recruiting
Conditions
Acute Myeloid Leukemia
Blastic Plasmacytoid Dendritic Cell Neoplasm
Myelodysplastic Syndrome
Interventions
First Posted Date
2017-04-13
Last Posted Date
2025-06-19
Lead Sponsor
Dana-Farber Cancer Institute
Target Recruit Count
72
Registration Number
NCT03113643
Locations
🇺🇸

City of Hope, Duarte, California, United States

🇺🇸

Dana Farber Cancer Institute, Boston, Massachusetts, United States

🇺🇸

MD Anderson Cancer Center, Houston, Texas, United States

Selinexor in Combination With Fludarabine and Cytarabine in Patients With Refractory or Relapsed Acute Myeloid Leukemia

Phase 2
Terminated
Conditions
Acute Myeloid Leukemia (AML)
Interventions
Drug: methotrexate/hydrocortisone/cytarabine
First Posted Date
2017-03-06
Last Posted Date
2020-05-22
Lead Sponsor
St. Jude Children's Research Hospital
Target Recruit Count
37
Registration Number
NCT03071276
Locations
🇺🇸

Phoenix Children's Hospital, Phoenix, Arizona, United States

🇺🇸

Lucile Packard Children's Hospital Stanford University, Palo Alto, California, United States

🇺🇸

University of Chicago, Chicago, Illinois, United States

and more 4 locations

Expanded Access Study of Gilteritinib (ASP2215) in Patients With FMS-like Tyrosine Kinase 3 (FLT3) Mutated Relapsed or Refractory Acute Myeloid Leukemia (AML) or FLT3-Mutated AML in Complete Remission (CR) With Minimal Residual Disease (MRD)

Conditions
Acute Myeloid Leukemia (AML)
FMS-like Tyrosine Kinase-3 (FLT3) Mutations
First Posted Date
2017-03-03
Last Posted Date
2021-04-20
Lead Sponsor
Astellas Pharma Global Development, Inc.
Registration Number
NCT03070093
Locations
🇺🇸

UCLA, Los Angeles, California, United States

🇺🇸

Rocky Mountain Cancer Center-M, Aurora, Colorado, United States

🇺🇸

Memorial Healthcare System, Pembroke Pines, Florida, United States

and more 36 locations

A Study of Venetoclax in Combination With Low Dose Cytarabine Versus Low Dose Cytarabine Alone in Treatment Naive Patients With Acute Myeloid Leukemia Who Are Ineligible for Intensive Chemotherapy

Phase 3
Completed
Conditions
Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2017-03-03
Last Posted Date
2025-08-20
Lead Sponsor
AbbVie
Target Recruit Count
211
Registration Number
NCT03069352
Locations
🇺🇸

H. Lee Moffit Cancer Center /ID# 164273, Tampa, Florida, United States

🇺🇸

Norton Cancer Institute /ID# 158998, Louisville, Kentucky, United States

🇺🇸

Univ of Pittsburgh Med Ctr /ID# 158997, Pittsburgh, Pennsylvania, United States

and more 106 locations

Treatment Patterns and Key Healthcare Resource Use in Acute Myeloid Leukemia (AML) With or Without FMS-like Tyrosine Kinase-3 (FLT3) Mutation Study Based on Retrospective Chart Review

Completed
Conditions
Acute Myeloid Leukemia (AML)
First Posted Date
2017-02-08
Last Posted Date
2024-11-05
Lead Sponsor
Astellas Pharma Global Development, Inc.
Target Recruit Count
1027
Registration Number
NCT03047083
Locations
🇺🇸

Sermo, Charlotte, North Carolina, United States

A Study of ARGX-110 in Combination With Azacytidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) or High Risk Myelodysplatic Syndrome (MDS)

Phase 1
Completed
Conditions
Leukemia, Myeloid, Acute
Myelodysplastic Syndromes
Interventions
First Posted Date
2017-01-25
Last Posted Date
2023-08-09
Lead Sponsor
OncoVerity, Inc.
Target Recruit Count
38
Registration Number
NCT03030612

A Trial of the FMS-like Tyrosine Kinase 3 (FLT3) Inhibitor Gilteritinib Administered as Maintenance Therapy Following Allogeneic Transplant for Patients With FLT3/Internal Tandem Duplication (ITD) Acute Myeloid Leukemia (AML)

Phase 3
Completed
Conditions
Acute Myeloid Leukemia
Interventions
Drug: Placebo
First Posted Date
2016-12-19
Last Posted Date
2025-01-17
Lead Sponsor
Astellas Pharma Global Development, Inc.
Target Recruit Count
356
Registration Number
NCT02997202
Locations
🇺🇸

University of Alabama at Birmingham, Birmingham, Alabama, United States

🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇺🇸

Virginia G Piper Cancer Center, Scottsdale, Arizona, United States

and more 114 locations

A Study of Venetoclax in Combination With Azacitidine Versus Azacitidine in Treatment Naïve Participants With Acute Myeloid Leukemia Who Are Ineligible for Standard Induction Therapy

Phase 3
Active, not recruiting
Conditions
Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2016-12-15
Last Posted Date
2025-08-19
Lead Sponsor
AbbVie
Target Recruit Count
443
Registration Number
NCT02993523
Locations
🇺🇸

City of Hope /ID# 154105, Duarte, California, United States

🇺🇸

University of California, Los Angeles /ID# 154107, Los Angeles, California, United States

🇺🇸

University of California, Davis Comprehensive Cancer Center /ID# 162725, Sacramento, California, United States

and more 169 locations

Single Agent JNJ-56022473 in MDS and AML Patients FAILING HYPOMETHYLATING AGENT BASED THERAPY

Phase 2
Terminated
Conditions
Acute Myeloid Leukemia (AML)
Myelodysplastic Syndrome (MDS)
Interventions
Procedure: Bone marrow analyses and CBC with differential
Other: Flow cytometry analyses
Other: Central biobanking
Procedure: Histopathology analysis
Genetic: Cytogenetic analysis
Procedure: Serum chemistry
Procedure: Automated CBC
Procedure: Pregnancy Test
First Posted Date
2016-12-14
Last Posted Date
2018-10-25
Lead Sponsor
GWT-TUD GmbH
Target Recruit Count
25
Registration Number
NCT02992860
Locations
🇫🇷

CHU Nantes, Nantes, France

🇫🇷

Hospital Archet 1, Nice, France

🇫🇷

Hospital Saint Louis, Paris, France

and more 7 locations

Phase 2 Study of Quizartinib in Participants With Acute Myeloid Leukemia (AML) FLT3 Internal Tandem Duplication (FLT3/ITD) Mutation

Phase 2
Completed
Conditions
Leukemia, Myeloid, Acute
Interventions
First Posted Date
2016-12-07
Last Posted Date
2020-02-17
Lead Sponsor
Daiichi Sankyo Co., Ltd.
Target Recruit Count
37
Registration Number
NCT02984995

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