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HCT With PTCy in Higher-risk MDS

Phase 2
Active, not recruiting
Conditions
Patients With MDS, Acute Myeloid Leukemia (AML) Evolving From MDS, and Chronic Myelomonocytic Leukemia (CMML)
Interventions
First Posted Date
2023-10-24
Last Posted Date
2023-10-24
Lead Sponsor
Asan Medical Center
Target Recruit Count
113
Registration Number
NCT06098313
Locations
🇰🇷

Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of

Study to Evaluate Adverse Events and Movement of Intravenously (IV) Infused ABBV-787 in Adult Participants With Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Phase 1
Terminated
Conditions
Acute Myeloid Leukemia
Interventions
First Posted Date
2023-10-05
Last Posted Date
2025-03-06
Lead Sponsor
AbbVie
Target Recruit Count
36
Registration Number
NCT06068868
Locations
🇺🇸

University of Maryland, Baltimore /ID# 253726, Baltimore, Maryland, United States

🇦🇺

Monash Health - Monash Medical Centre /ID# 253841, Clayton, Victoria, Australia

🇺🇸

City of Hope /ID# 253727, Duarte, California, United States

and more 21 locations

A Study to Asses Effectiveness and Treatment Management of Oral Venetoclax Tablets + Subcutaneously Injected Azacitidine in Adult Participants Ineligible for Intensive Chemotherapy With de Novo Acute Myeloid Leukemia (AML) in Italy

Active, not recruiting
Conditions
Acute Myeloid Leukemia
First Posted Date
2023-09-28
Last Posted Date
2025-04-22
Lead Sponsor
AbbVie
Target Recruit Count
150
Registration Number
NCT06058741
Locations
🇮🇹

IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 259535, Bologna, Italy

🇮🇹

Azienda Ospedaliera Universitaria Integrata di Verona /ID# 260809, Verona, Italy

🇮🇹

Azienda Ospedaliero Universitaria Careggi /ID# 259766, Florence, Firenze, Italy

and more 25 locations

A Phase 1 Clinical Trail of NTQ2494 Tablets in Patients With Advanced Hematological Malignancies

Phase 1
Recruiting
Conditions
Relapsed/Refractory Acute Myeloid Leukemia (AML)
Interventions
Drug: NTQ2494 tablet
First Posted Date
2023-09-22
Last Posted Date
2023-09-22
Lead Sponsor
Nanjing Chia-tai Tianqing Pharmaceutical
Target Recruit Count
72
Registration Number
NCT06049667
Locations
🇨🇳

Hematology Hospital of the Chinese Academy of Medical Sciences, Tianjin, Tianjin, China

A Study to Evaluate the STI-8591 in Subjects With Advanced Acute Myeloid Leukemia (AML)

Phase 1
Recruiting
Conditions
AML, Adult
Interventions
First Posted Date
2023-07-17
Last Posted Date
2025-03-17
Lead Sponsor
Zhejiang ACEA Pharmaceutical Co. Ltd.
Target Recruit Count
84
Registration Number
NCT05947344
Locations
🇨🇳

the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

A Study of BL-M11D1 in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Phase 1
Recruiting
Conditions
Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)
Interventions
First Posted Date
2023-06-29
Last Posted Date
2025-08-03
Lead Sponsor
Sichuan Baili Pharmaceutical Co., Ltd.
Target Recruit Count
130
Registration Number
NCT05924750
Locations
🇨🇳

Anhui Provincial Hospital, Hefei, Anhui, China

🇨🇳

Beijing Hospital, Beijing, Beijing, China

🇨🇳

Institute of Hematology, the First Hospital of Harbin, Haerbin, Heilongjiang, China

and more 5 locations

An Open-label Phase 3b Study of Ivosidenib in Combination With Azacitidine in Adult Patients Newly Diagnosed With IDH1m Acute Myeloid Leukemia (AML) Ineligible for Intensive Induction Chemotherapy.

Phase 3
Recruiting
Conditions
Acute Myeloid Leukemia (AML)
Interventions
First Posted Date
2023-06-18
Last Posted Date
2025-04-11
Lead Sponsor
Servier Affaires Médicales
Target Recruit Count
245
Registration Number
NCT05907057
Locations
🇦🇹

AKH - Medizinische Universität Wien, Vienna, Austria

🇦🇹

Klinikum Wels-Grieskirchen GmbH, Wels, Austria

🇫🇷

Institut Paoli Calmettes, Marseille, Bouches-du-Rhône, France

and more 12 locations

CPI-613 Given With Metformin in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)

Phase 2
Not yet recruiting
Conditions
Acute Myeloid Leukemia, in Relapse
Acute Myeloid Leukemia Refractory
Granulocytic Sarcoma
Interventions
Biological: Blood draws
Procedure: Bone marrow biopsy
First Posted Date
2023-05-11
Last Posted Date
2024-08-07
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
17
Registration Number
NCT05854966

A Phase Ib Trial of Azacitidine, Venetoclax and Allogeneic NK Cells for Acute Myeloid Leukemia (ADVENT-AML)

Phase 1
Recruiting
Conditions
Acute Myeloid Leukemia
Interventions
First Posted Date
2023-04-28
Last Posted Date
2025-06-04
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
32
Registration Number
NCT05834244
Locations
🇺🇸

M.D. Anderson Cancer Center, Houston, Texas, United States

Venetoclax in Combination with 5 Days Azacitidine in Untreated AML Patients, Not Eligible for Standard Induction Therapy

Phase 2
Recruiting
Conditions
Acute Myeloid Leukemia (AML)
Interventions
Drug: VEN+AZA-5
First Posted Date
2023-04-27
Last Posted Date
2024-12-09
Lead Sponsor
University of Leipzig
Target Recruit Count
45
Registration Number
NCT05833438
Locations
🇩🇪

Helios Klinikum Berlin-Buch Klinik für Hämatologie und Stammzelltransplantation, Berlin, Germany

🇩🇪

Klinikum Chemnitz gGmbH Klinik für lnnere Medizin Ill, Chemnitz, Germany

🇩🇪

Carl-Thiem-Klinikum Cottbus gGmbH, Cottbus, Germany

and more 7 locations

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