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RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors

Phase 1

Active, not recruiting

Conditions: Recurrent Pulmonary Osteosarcoma
Recurrent High-grade Glioma

Interventions: Biological: pp65 RNA LP (DP1)
Biological: pp65/tumor mRNA RNA-LP (DP2)
Procedure: Surgical Biopsy/Resection

First Posted Date: 2022-12-21

Last Posted Date: 2025-05-14

Lead Sponsor: University of Florida

Target Recruit Count: 36

Registration Number: NCT05660408

Locations: 🇺🇸
UF Health, Gainesville, Florida, United States

Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects

Phase 2

Recruiting

Conditions: Healthy Lifestyle
Obesity

Interventions: Procedure: Abdominal adipose tissue biopsy
Other: Lifestyle Intervention
Drug: Dasatinib 100 MG
Drug: Quercetin 1000mg
Drug: Placebo

First Posted Date: 2022-12-16

Last Posted Date: 2025-03-24

Lead Sponsor: Cedars-Sinai Medical Center

Target Recruit Count: 160

Registration Number: NCT05653258

Locations: 🇺🇸
Cedars Sinai Medical Center, Los Angeles, California, United States

Evaluation of OLX10212 in Patients With Neovascular Age-related Macular Degeneration

Phase 1

Recruiting

Conditions: Neovascular Age-related Macular Degeneration

Interventions: Genetic: OLX10212 is a cell penetrating asymmetric small interference RNA (cp-asiRNA)

First Posted Date: 2022-12-08

Last Posted Date: 2024-02-21

Lead Sponsor: Olix Pharmaceuticals, Inc.

Target Recruit Count: 42

Registration Number: NCT05643118

Locations: 🇺🇸
California Retina Consultants, Santa Maria, California, United States
🇺🇸
University Retina, Oak Forest, Illinois, United States
🇺🇸
The Retina Institute, Saint Louis, Missouri, United States

and more 2 locations

Humoral and Cellular Immunity Against SARS-COV-2 Vaccine in HIV-infected Patients Immunosuppressed

Completed

Conditions: SARS-CoV-2 RNA Vaccines
HIV Infection

Interventions: Biological: SARS-CoV-2 Vaccine

First Posted Date: 2022-12-01

Last Posted Date: 2024-10-11

Lead Sponsor: Hospitales Universitarios Virgen del Rocío

Target Recruit Count: 48

Registration Number: NCT05633927

Locations: 🇪🇸
Virgen del Rocio University Hospital, Sevilla, Spain

Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery

Not Applicable

Recruiting

Conditions: Heart Failure NYHA Class II
Ischemic Heart Disease
Heart Failure NYHA Class III
Heart Failure NYHA Class IV
Ischemic Cardiomyopathy
Heart Failure, Systolic
Coronary Artery Disease

Interventions: Procedure: Epicardial AAMs-patch transplantation
Diagnostic Test: Plasma sampling
Diagnostic Test: RNA-stabilized whole blood sampling
Diagnostic Test: Transthoracic echocardiography
Diagnostic Test: Late-gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMRI)
Other: Symptom-scaling
Other: 6-minute walking test (6MWT)
Diagnostic Test: Blood sampling (NT-proBNP)
Diagnostic Test: Transesophageal echocardiography
Procedure: Epicardial collagen-based patch transplantation

First Posted Date: 2022-11-30

Last Posted Date: 2024-04-19

Lead Sponsor: Hospital District of Helsinki and Uusimaa

Target Recruit Count: 50

Registration Number: NCT05632432

Locations: 🇫🇮
Hospital District of Helsinki and Uusimaa, Helsinki University Hospital, Heart and Lung Center & Cardiac Unit, Helsinki, Uusimaa, Finland

A Study to Learn About Bivalent COVID-19 RNA Vaccine Candidate(s) in Healthy Infants and Children

Phase 1

Withdrawn

Conditions: COVID-19

Interventions: Biological: Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 10 microgram dose
Biological: Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 3 microgram dose
Biological: Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 6 microgram dose
Biological: Bivalent BNT162b2 (original/Omicron BA.4/BA.5) 1 microgram dose

First Posted Date: 2022-11-29

Last Posted Date: 2024-03-18

Lead Sponsor: BioNTech SE

Registration Number: NCT05630352

Impact of Transforaminal Epidural Steroid Injection in Lumbar Disc Prolpse on Micro RNA-155 Serum Level

Phase 4

Completed

Conditions: Lumbar Disc Herniation

Interventions: Drug: transforaminal epidural injection.
Other: micro RNA-155 serum level

First Posted Date: 2022-11-23

Last Posted Date: 2024-05-29

Lead Sponsor: Beni-Suef University

Target Recruit Count: 88

Registration Number: NCT05626283

Locations: 🇪🇬
Mona Hussein, Banī Suwayf, Beni-Suef, Egypt

Rutgers Pilot for PREDICT- Patient LAB Test

Not Applicable

Completed

Conditions: SARS-CoV2 Infection

Interventions: Device: Testing for SARS CoV2 RNA

First Posted Date: 2022-11-07

Last Posted Date: 2023-09-22

Lead Sponsor: Rutgers, The State University of New Jersey

Target Recruit Count: 11

Registration Number: NCT05607043

Locations: 🇺🇸
Rutgers School of Dental Medicine, Newark, New Jersey, United States

CML Pediatric ITK Response According to Molecular Identification at Diagnosis

Recruiting

Conditions: Chronic Myeloid Leukemia

Interventions: Biological: Next Generation Sequencing (DNA and RNA)

First Posted Date: 2022-11-04

Last Posted Date: 2024-08-14

Lead Sponsor: University Hospital, Bordeaux

Target Recruit Count: 88

Registration Number: NCT05605379

Locations: 🇫🇷
CHU de Bordeaux, Service Hématologie Biologique, Bordeaux, France

Clinical Validation Study for EDIT-B Test: an Aid for Differential Diagnosis of Bipolar Disorder, Based on RNA Editing Blood Biomarkers

Completed

Conditions: Major Depressive Disorder
Bipolar Disorder

Interventions: Device: EDIT-B

First Posted Date: 2022-11-03

Last Posted Date: 2024-12-17

Lead Sponsor: Alcediag

Target Recruit Count: 418

Registration Number: NCT05603819

Locations: 🇩🇰
The Capital Region of Denmark, Copenhagen, Denmark
🇫🇷
GHU Paris Psychiatrie & Neurosciences, Paris, France
🇪🇸
Parc Sanitari Sant Joan de Déu, Sant Boi De Llobregat, Barcelona, Spain

and more 1 locations