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Open-laBel Dose-escalation Study for CRISPR/cas13- Rna TargetInG THerapy for the Treatment of Neovascular Age-related Macular Degeneration in Phase I Trial

Phase 1

Not yet recruiting

Conditions: Neovascular Age-Related Macular Degeneration (nAMD)

Interventions: Genetic: HG202

First Posted Date: 2024-10-02

Last Posted Date: 2024-10-02

Lead Sponsor: HuidaGene Therapeutics Co., Ltd.

Target Recruit Count: 15

Registration Number: NCT06623279

First-in-Human Pilot Study of Epicardial Circular RNA-HM2002 Injection in CABG for Ischemic Heart Failure

Early Phase 1

Active, not recruiting

Conditions: Ischaemic Heart Disease
Heart Failure

Interventions: Drug: HM2002 injection

First Posted Date: 2024-10-01

Last Posted Date: 2025-04-02

Lead Sponsor: Ruijin Hospital

Target Recruit Count: 3

Registration Number: NCT06621576

Locations: 🇨🇳
Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China

A First-in-Human Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of a Novel CRISPR RNA-editing Therapy in Patients with Mecp2 Duplication Syndrome, a Rare Orphan Disease (HERO)

Not Applicable

Recruiting

Conditions: MECP2 Duplication Syndrome

Interventions: Genetic: HG204

First Posted Date: 2024-09-26

Last Posted Date: 2024-11-26

Lead Sponsor: HuidaGene Therapeutics Co., Ltd.

Target Recruit Count: 6

Registration Number: NCT06615206

A Study of the RNA Tumor Vaccine Targeting MICA/B in Patients with Advanced Solid Tumors

Early Phase 1

Not yet recruiting

Conditions: Advanced Solid Tumors

Interventions: Biological: SapRNA™-MICA/B Tumor Vaccine

First Posted Date: 2024-09-24

Last Posted Date: 2024-09-24

Lead Sponsor: NING LI

Target Recruit Count: 18

Registration Number: NCT06610227

Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

Recruiting

Conditions: Congenital Melanocytic Nevi
Melanoma, Skin
Nevi and Melanomas

Interventions: Genetic: Methylomics
Genetic: RNA sequencing
Genetic: Spatial transcriptomics
Genetic: Liquid biopsy

First Posted Date: 2024-09-20

Last Posted Date: 2025-02-27

Lead Sponsor: Fundacion Clinic per a la Recerca Biomédica

Target Recruit Count: 100

Registration Number: NCT06605417

Locations: 🇫🇷
French National Institute of Health and Medical Research, Marseille, France
🇪🇸
Hospital Clínic de Barcelona (Dermatology service), Barcelona, Spain

Safety and Immunogenicity Study of Self-Amplifying RNA Pandemic Influenza Vaccine in Adults

Phase 1

Not yet recruiting

Conditions: Influenza, Human

Interventions: Biological: ARCT-2304
Biological: Control vaccine younger adults
Biological: Control vaccine older adults
Other: Placebo Vaccine

First Posted Date: 2024-09-19

Last Posted Date: 2024-09-19

Lead Sponsor: Arcturus Therapeutics, Inc.

Target Recruit Count: 200

Registration Number: NCT06602531

Plasma Exosome RNA to Diagnose Prostate Cancer

Not Applicable

Conditions: Prostate Cancer

Interventions: Diagnostic Test: Prostate cancer screening decision

First Posted Date: 2024-09-19

Last Posted Date: 2025-04-22

Lead Sponsor: Xijing Hospital

Target Recruit Count: 1200

Registration Number: NCT06604130

Locations: 🇨🇳
Xijing Hospital, Xian, Shaanxi, China

Effect of Small Interfering RNA Inclisiran on Carotid Plaques As Assessed by Carotid Ultrasound

Phase 4

Not yet recruiting

Conditions: Carotid Plaque
Hyperlipidemia
Echocardiography

Interventions: Drug: Inclisiran

First Posted Date: 2024-09-06

Last Posted Date: 2024-09-06

Lead Sponsor: First Affiliated Hospital of Xinjiang Medical University

Target Recruit Count: 40

Registration Number: NCT06586684

Combined Genome and RNA Sequencing for Genetic Diagnosis of Parkinsonism

Not Applicable

Not yet recruiting

Conditions: Parkinson's Disease

Interventions: Diagnostic Test: Combiner whole genome and RNA sequencing

First Posted Date: 2024-08-29

Last Posted Date: 2024-08-29

Lead Sponsor: University Hospital, Strasbourg, France

Target Recruit Count: 14

Registration Number: NCT06576713

Using the Chemical Modifications Present on RNA Molecules to Diagnose and Treat Brain Cancer

Not Applicable

Not yet recruiting

Conditions: Glioma

Interventions: Diagnostic Test: Blood, urine and tumoral tissue samples
Diagnostic Test: Tumoral tissue samples

First Posted Date: 2024-08-28

Last Posted Date: 2025-02-11

Lead Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle

Target Recruit Count: 228

Registration Number: NCT06575452

Locations: 🇫🇷
Insitut Régional du Cancer de Montpellier, Montpellier, Hérault, France
🇫🇷
CHU Montpellier - Hôpital St Eloi, Montpellier, France