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Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia

Phase 3

Recruiting

Conditions: Hypertriglyceridemia

Interventions: Drug: Placebo
Drug: Plozasiran Injection

First Posted Date: 2024-04-04

Last Posted Date: 2025-03-25

Lead Sponsor: Arrowhead Pharmaceuticals

Target Recruit Count: 1328

Registration Number: NCT06347133

Locations: 🇺🇸
University of Louisville Research Foundation, Louisville, Kentucky, United States
🇺🇸
University of Minnesota Medical Center, Minneapolis, Minnesota, United States
🇺🇸
Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States

and more 228 locations

Study of Plozasiran in Adults With Severe Hypertriglyceridemia

Phase 3

Recruiting

Conditions: Severe Hypertriglyceridemia

Interventions: Drug: Plozasiran Injection
Drug: Placebo

First Posted Date: 2024-04-04

Last Posted Date: 2025-03-26

Lead Sponsor: Arrowhead Pharmaceuticals

Target Recruit Count: 300

Registration Number: NCT06347016

Locations: 🇺🇸
Ascension St. Vincents Birmingham, Birmingham, Alabama, United States
🇺🇸
IMC-Diagnostic and Medical Clinic LLC, Mobile, Alabama, United States
🇺🇸
National Heart Institute, Beverly Hills, California, United States

and more 145 locations

The Epigenetic Regulatory Role of P-element Induced Wimpy Testis (Piwi) Interacting RNA-823 (piR-823) in Ovarian Cancer Progression

Active, not recruiting

Conditions: Ovarian Cancer

First Posted Date: 2024-03-20

Last Posted Date: 2024-03-20

Lead Sponsor: Ain Shams University

Target Recruit Count: 56

Registration Number: NCT06320418

Locations: 🇪🇬
Faculty of Pharmacy, Ain Shams University, Advanced Biochemistry Research Lab, Cairo, Egypt

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

Phase 2

Recruiting

Conditions: Advanced Malignant Solid Neoplasm
Metastatic Malignant Solid Neoplasm

Interventions: Procedure: Biopsy Procedure
Other: Electronic Health Record Review
Procedure: Biospecimen Collection
Other: Immunohistochemistry Staining Method
Procedure: Computed Tomography
Drug: Enfortumab Vedotin
Procedure: Echocardiography Test
Procedure: Magnetic Resonance Imaging
Biological: Sacituzumab Govitecan
Procedure: Multigated Acquisition Scan
Biological: Trastuzumab Deruxtecan

First Posted Date: 2024-03-15

Last Posted Date: 2025-06-05

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 500

Registration Number: NCT06311214

Locations: 🇺🇸
UC San Diego Health System - Encinitas, Encinitas, California, United States
🇺🇸
UC San Diego Medical Center - Hillcrest, San Diego, California, United States
🇺🇸
UC San Diego Moores Cancer Center, La Jolla, California, United States

and more 1 locations

Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19

Not Applicable

Recruiting

Conditions: Long COVID

Interventions: Diagnostic Test: RNA Biomarker Blood Test

First Posted Date: 2024-03-15

Last Posted Date: 2024-10-18

Lead Sponsor: MaxWell Clinic, PLC

Target Recruit Count: 224

Registration Number: NCT06311435

Locations: 🇺🇸
University of Iowa, Iowa City, Iowa, United States
🇺🇸
The MaxWell Clinic, Brentwood, Tennessee, United States

GENETIC VARIABILITY TO GLP1 TREATMENT

Not Applicable

Recruiting

Conditions: Obesity
Type 2 Diabetes

Interventions: Genetic: DNA Sequencing and Analysis
Genetic: differential expression analysis with RNA-sequencing (RNA seq) experiments

First Posted Date: 2024-03-07

Last Posted Date: 2024-03-07

Lead Sponsor: GENGE

Target Recruit Count: 400

Registration Number: NCT06298799

Locations: 🇮🇱
Rambem medical center, Haifa, Israel

The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple Scelerosis

Not yet recruiting

Conditions: Multiple Sclerosis

Interventions: Diagnostic Test: micro RNA 27- FLP1 gene expression
Diagnostic Test: The Expanded Disability Status Scale (EDSS)

First Posted Date: 2024-03-04

Last Posted Date: 2024-03-04

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT06290453

Assessment Of Serum And Tissue Levels Of Cold-Inducible RNA-Binding Protein In Patients With Lichen Planus

Recruiting

Conditions: Assessment, Self

First Posted Date: 2024-02-15

Last Posted Date: 2024-02-15

Lead Sponsor: Sohag University

Target Recruit Count: 80

Registration Number: NCT06260189

Locations: 🇪🇬
Aya Ahmed Elsayed, Sohag, Egypt

MicroRNAs as Bile-based Biomarkers in Pancreaticobiliary Cancers

Completed

Conditions: Gallstone Disease
Biliary Stricture
Ampullary Cancer
Pancreatic Cancer
Cholangiocarcinoma

Interventions: Diagnostic Test: Small RNA Sequencing and Validation of candidate miRNAs

First Posted Date: 2024-02-14

Last Posted Date: 2024-02-14

Lead Sponsor: Imperial College London

Target Recruit Count: 229

Registration Number: NCT06258824

Locations: 🇬🇧
Imperial College Healthcare NHS Trust, London, United Kingdom

Time to Clearance of Chlamydia Trachomatis and Neisseria Gonorrhoeae RNA After Treatment: a Prospective Cohort Study

Not Applicable

Recruiting

Conditions: Neisseria Gonorrhoeae
Uncomplicated Infections
Chlamydia Trachomatis

First Posted Date: 2024-01-22

Last Posted Date: 2024-08-19

Lead Sponsor: University Hospital, Strasbourg, France

Target Recruit Count: 140

Registration Number: NCT06216964

Locations: 🇫🇷
Service du Trait d'Union, Strasbourg, France

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