MedPath

Magnesium

Generic Name
Magnesium
Brand Names
Vitafol-one
Drug Type
Small Molecule
Chemical Formula
H2Mg
CAS Number
7439-95-4
Unique Ingredient Identifier
I38ZP9992A
Background

Magnesium is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.

Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens. Magnesium is an important enzyme cofactor and is essential to several metabolic processes. Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions.

Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium. Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium).

Indication

Healthy levels of magnesium can be achieved through a well balanced diet, but if food sources are insufficient, magnesium supplements can be used to prevent and treat magnesium deficiencies.

In medicine, various magnesium salts may be used in laxative and antacid products. For example, magnesium citrate is available over-the-counter and may be used to manage occasional constipation. Magnesium sulfate may be used on its own or with total parenteral nutrition to treat hypomagnesemia. Magnesium sulfate is also indicated to prevent seizures in pregnant women with pre-eclampsia, and to manage seizures associated with eclampsia.

Associated Conditions
Calcium Deficiency, Magnesium Deficiency, Zinc Deficiency

Enhancing Neonatal Sucking Reflex: A Study on the Efficacy of Magnesium Sulphate in Severe Birth Asphyxia

Not Applicable
Completed
Conditions
Birth Asphyxia
Interventions
Drug: Magnesium Sulphate infusion
First Posted Date
2024-06-21
Last Posted Date
2024-06-24
Lead Sponsor
RESnTEC, Institute of Research
Target Recruit Count
80
Registration Number
NCT06468475
Locations
🇵🇰

The Children's Hospital and the Institute of Child Health, Multan, Punjab, Pakistan

Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or II

Phase 3
Recruiting
Conditions
Hereditary Angioedema
Interventions
Drug: KVD900 75 mg
Drug: KVD900 150 mg
Drug: KVD900 300 mg
First Posted Date
2024-06-20
Last Posted Date
2025-04-11
Lead Sponsor
KalVista Pharmaceuticals, Ltd.
Target Recruit Count
36
Registration Number
NCT06467084
Locations
🇯🇵

KalVista Investigative Site, Tokyo, Japan

Study to Evaluate the Efficacy and Safety of JP-1366 in the Prevention of NSAIDs-Induced Peptic Ulcers

Phase 3
Recruiting
Conditions
Peptic Ulcer
Interventions
Drug: Lanston Capsule 15 mg
Drug: JP-1366 10 mg
Drug: Lanston Capsule 15 mg placebo
Drug: JP-1366 10 mg placebo
First Posted Date
2024-06-03
Last Posted Date
2024-11-01
Lead Sponsor
Onconic Therapeutics Inc.
Target Recruit Count
364
Registration Number
NCT06439563
Locations
🇰🇷

Konkuk University Medical Center, Seoul, Korea, Republic of

Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout Patients (AR882-302)

Phase 3
Active, not recruiting
Conditions
Gout Chronic
Gout
Arthritis, Gouty
Hyperuricemia
Interventions
Drug: Placebo
Drug: AR882 75 mg
Drug: AR882 50 mg
First Posted Date
2024-06-03
Last Posted Date
2025-04-15
Lead Sponsor
Arthrosi Therapeutics
Target Recruit Count
750
Registration Number
NCT06439602
Locations
🇨🇳

Arthrosi Investigative Site (402), Taichung, Taiwan

🇨🇳

Arthrosi Investigative Site (400), Taipei, Taiwan

🇨🇳

Arthrosi Investigative Site (403), Taipei, Taiwan

and more 65 locations

To Evaluate the Effects of NMRA-335140 on Symptoms of Major Depression in Participants With Bipolar II Disorder.

Phase 2
Active, not recruiting
Conditions
Major Depressive Episode Associated With Bipolar II Disorder
Interventions
Drug: Placebo
Drug: NMRA-335140 80 mg
First Posted Date
2024-05-28
Last Posted Date
2025-05-16
Lead Sponsor
Neumora Therapeutics, Inc.
Target Recruit Count
60
Registration Number
NCT06429722
Locations
🇺🇸

Neumora Investigator Site, Bellevue, Washington, United States

The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.

First Posted Date
2024-05-24
Last Posted Date
2024-10-09
Lead Sponsor
Ain Shams University
Target Recruit Count
90
Registration Number
NCT06427707
Locations
🇪🇬

Ain Shams University, Cairo, Egypt

Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population

Phase 1
Recruiting
Conditions
Healthy Volunteers
Interventions
Drug: MAM01 150 mg SC
Drug: MAM01 150 mg IM
Drug: MAM01 100 mg SC
Drug: MAM01 300 mg SC
Drug: MAM01 300 mg IM
Drug: MAM01 2000 mg IV
Drug: MAM01 190 mg SC
Drug: MAM01 225 mg SC
Drug: MAM01 150 mg IV
Drug: Placebo SC
Drug: Placebo IM
Drug: Placebo IV
First Posted Date
2024-05-10
Last Posted Date
2025-04-08
Lead Sponsor
Bill & Melinda Gates Medical Research Institute
Target Recruit Count
139
Registration Number
NCT06408857
Locations
🇺🇬

JCRC-Joint Clinical Research Centre, Kampala, Uganda

🇺🇬

IDRC-Infectious Disease Research Collaboration, IDRC Tororo Hospital Station Road, Tororo, Uganda

Single Ascending Oral Dose Study to Investigate the Effects of OCT461201 in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: OCT461201 100 mg
Drug: OCT461201 150 mg
Drug: OCT461201 450 mg
Drug: OCT461201 50 mg
Drug: Placebo
First Posted Date
2024-05-03
Last Posted Date
2024-05-03
Lead Sponsor
Oxford Cannabinoid Technologies Holdings PLC
Target Recruit Count
32
Registration Number
NCT06398925
Locations
🇬🇧

Simbec-Orion, Merthyr Tydfil, United Kingdom

Study to Evaluate the Efficacy and Safety of XC243 in Patients With Exacerbation of Chronic Cystitis

Phase 2
Not yet recruiting
Conditions
Cystitis
Interventions
Drug: XC243 50 mg
Drug: Placebo
Drug: XC243 25 mg
Drug: XC243 75 mg
First Posted Date
2024-04-30
Last Posted Date
2024-04-30
Lead Sponsor
PHARMENTERPRISES LLC
Target Recruit Count
280
Registration Number
NCT06391164
Locations
🇷🇺

LLC "Clinic Zvezdnaya", Saint Petersburg, Russian Federation

🇷🇺

St. Petersburg State Budgetary Healthcare Institution "City Polyclinic № 112", Saint Petersburg, Russian Federation

🇷🇺

LLC "Research Center Eco-Safety", Saint Petersburg, Russian Federation

and more 4 locations

Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR

Phase 3
Recruiting
Conditions
Tachycardia Atrial
Atrial Fibrillation
Atrial Flutter With Rapid Ventricular Response
Interventions
Drug: Saline
Drug: Magnesium Sulfate 2 G
Drug: Magnesium Sulfate 4 G
First Posted Date
2024-04-22
Last Posted Date
2024-11-18
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
153
Registration Number
NCT06376916
Locations
🇺🇸

Advocate Christ Medical Center Emergency Department (ACMC ED), Oak Lawn, Illinois, United States

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