MedPath

Magnesium

Generic Name
Magnesium
Brand Names
Vitafol-one
Drug Type
Small Molecule
Chemical Formula
H2Mg
CAS Number
7439-95-4
Unique Ingredient Identifier
I38ZP9992A
Background

Magnesium is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate.

Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens. Magnesium is an important enzyme cofactor and is essential to several metabolic processes. Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions.

Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium. Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium).

Indication

Healthy levels of magnesium can be achieved through a well balanced diet, but if food sources are insufficient, magnesium supplements can be used to prevent and treat magnesium deficiencies.

In medicine, various magnesium salts may be used in laxative and antacid products. For example, magnesium citrate is available over-the-counter and may be used to manage occasional constipation. Magnesium sulfate may be used on its own or with total parenteral nutrition to treat hypomagnesemia. Magnesium sulfate is also indicated to prevent seizures in pregnant women with pre-eclampsia, and to manage seizures associated with eclampsia.

Associated Conditions
Calcium Deficiency, Magnesium Deficiency, Zinc Deficiency

GV1001 Subcutaneous(SC) for the Treatment of Progressive Supranuclear Palsy (PSP)

Phase 2
Completed
Conditions
Progressive Supranuclear Palsy
Interventions
Drug: GV1001 Placebo
Drug: GV1001 0.56mg
Drug: GV1001 1.12mg
First Posted Date
2023-04-19
Last Posted Date
2024-10-23
Lead Sponsor
GemVax & Kael
Target Recruit Count
78
Registration Number
NCT05819658
Locations
🇰🇷

Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of

🇰🇷

Kyung Hee University Hospital, Seoul, Korea, Republic of

🇰🇷

Samsung Medical Center, Seoul, Korea, Republic of

and more 2 locations

A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

Phase 2
Recruiting
Conditions
Bladder Spasms
Interventions
Drug: Placebo
First Posted Date
2023-04-10
Last Posted Date
2025-05-13
Lead Sponsor
Mayo Clinic
Target Recruit Count
120
Registration Number
NCT05806996
Locations
🇺🇸

Mayo Clinic in Minnesota, Rochester, Minnesota, United States

Evaluate Long-term Safety, Tolerability and Efficacy of Iptacopan in Study Participants With aHUS

Phase 3
Recruiting
Conditions
Atypical Hemolytic Uremic Syndrome
Interventions
Drug: Iptcaopan 200 mg
First Posted Date
2023-04-03
Last Posted Date
2025-04-06
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
125
Registration Number
NCT05795140
Locations
🇮🇳

Novartis Investigative Site, Pune, Maharashtra, India

A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes

Phase 2
Recruiting
Conditions
Type 1 Diabetes Mellitus with Hypoglycemia
Interventions
Drug: Placebo
Drug: ZT-01, 7 mg
Drug: ZT-01, 22 mg
Drug: ZT-01, 15 mg
First Posted Date
2023-03-09
Last Posted Date
2025-03-11
Lead Sponsor
Zucara Therapeutics Inc.
Target Recruit Count
186
Registration Number
NCT05762107
Locations
🇺🇸

Headlands Research, Escondido, California, United States

🇺🇸

USC Keck Medicine Eastside Center for Diabetes, Los Angeles, California, United States

🇺🇸

LCGK Research, San Carlos, California, United States

and more 22 locations

A Food Effect Study of TS-142 in Healthy Subjects

Phase 1
Completed
Conditions
Effect of Food
Interventions
Drug: TS-142 10 mg
First Posted Date
2023-02-01
Last Posted Date
2025-02-28
Lead Sponsor
Taisho Pharmaceutical Co., Ltd.
Target Recruit Count
12
Registration Number
NCT05707897
Locations
🇯🇵

Taisho Pharmaceutical Co., Ltd selected site, Tokyo, Japan

Acute Exacerbation of COPD and Nebulized Magnesium Sulphate

Not Applicable
Completed
Conditions
Magnesium Sulfate
Chronic Obstructive Pulmonary Disease Exacerbation
Interventions
Drug: Nebulized Magnesium Sulphate
First Posted Date
2023-01-26
Last Posted Date
2023-01-26
Lead Sponsor
King Edward Medical University
Target Recruit Count
160
Registration Number
NCT05699720
Locations
🇵🇰

Fawad Ahmad Randhawa, Lahore, Punjab, Pakistan

Phase IIa Proof of Concept Study of M5717-Pyronaridine in Adults and Adolescents With Acute Uncomplicated Plasmodium Falciparum Malaria (CAPTURE 1)

Phase 2
Completed
Conditions
Acute Malaria
Interventions
Drug: M5717 330 mg
Drug: M5717 500 mg
Drug: Pyronaridine-artesunate (Pyramax) 360 mg/120 mg
Drug: M5717 660 mg
Drug: Pyronaridine-artesunate (Pyramax) 720 mg/240 mg
First Posted Date
2023-01-18
Last Posted Date
2025-01-03
Lead Sponsor
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Target Recruit Count
38
Registration Number
NCT05689047
Locations
🇺🇬

Infectious Diseases Research Collaboration (IDRC), Tororo, Uganda

🇧🇫

Groupe de Recherche Action en Santé (GRAS), Ouagadougou, Burkina Faso

🇲🇿

Centro de Investigação em saúde de Manhiça/Fundação Manhiça (CISM/FM), Maputo, Mozambique

and more 2 locations

Magnesium Sulphate Neuroprotective Strategies for Preterm Deliveries

Phase 2
Recruiting
Conditions
NEUROPROTECTION
Premature Birth
MAGNESIUM SULPHATE
Cerebral Palsy
Neonatal Death
Interventions
Drug: Magnesium sulfate loading dose only
Drug: Magnesium sulfate loading with maintenance dose
First Posted Date
2023-01-06
Last Posted Date
2023-07-14
Lead Sponsor
Zagazig University
Target Recruit Count
336
Registration Number
NCT05674565
Locations
🇪🇬

Faculty of medicine, Zagazig University, Zagazig, Sharkia, Egypt

Treatment of Renal Colic in the Emergency Department: Comparison Between Magnesium Sulfate and Lidocaine.

Phase 2
Completed
Conditions
Renal Colic
Interventions
Drug: Magnesium sulfate and diclofenac
First Posted Date
2022-12-16
Last Posted Date
2023-09-21
Lead Sponsor
University of Monastir
Target Recruit Count
800
Registration Number
NCT05653401
Locations
🇹🇳

Emergency department of university hospital Fattouma Bourguiba of Monastir Monastir, Monastir Tunisia, Monastir, Tunisia

Intravenous Administration of Magnesium Sulfate in Hysterectomy Cases

Not Applicable
Completed
Conditions
Abdominal Hysterectomy
General Anesthesia
Magnesium Sulfate
Interventions
Drug: magnesium sulfate group
Drug: control group saline
First Posted Date
2022-12-09
Last Posted Date
2025-05-21
Lead Sponsor
Ondokuz Mayıs University
Target Recruit Count
48
Registration Number
NCT05644873
Locations
🇹🇷

Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey

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