Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Bendamustine is indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
Arizona Cancer Center at UMC North, Tucson, Arizona, United States
Concord Repatriation General Hospital; Haematology, Sydney, New South Wales, Australia
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
Oncology Associates of Oregon, P.C.; Willamette Valley Cancer Institute, Springfield, Oregon, United States
Good Samaritan Hospital, Torrance, California, United States
Saint Francis Cancer Treatment Center, Grand Island, Nebraska, United States
Uniwersyteckie Centrum Kliniczne, Gdańsk, Poland
Spedali Civili, Brescia, BS, Italy
AOU Città della Salute e della Scienza, Torino, TO, Italy
IRCCS Fondazione Pascale, Napoli, Italy
German CLL Study Group, Cologne, Germany
Kent & Canterbury Hospital, Canterbury, United Kingdom
Royal Liverpool Hospital, Liverpool, United Kingdom
Heartlands Hospitals, Birmingham, United Kingdom
University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States
CHR de Metz-Thionville - Hôpital de Mercy, Metz, France
Hôpital de la Pitié-Salpêtrière, Paris, France
CHRU de Nîmes, Nîmes, France
German CLL Study Group, Cologne, Germany
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