Carbetocin

Generic Name: Carbetocin

Brand Names: Duratocin

Drug Type: Small Molecule

Chemical Formula: C_₄₅H_₆₉N_₁₁O_₁₂S

CAS Number: 37025-55-1

Unique Ingredient Identifier: 88TWF8015Y

Background: Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus.

Indication: Used to control postpartum hemorrhage and bleeding after giving birth.

Associated Conditions: Postpartum Haemorrhage (PPH), Uterine Atony

Associated Therapies: -

Clinical Trials

Effects of Carbetocin and Oxytocin Used in Cesarean Sections on Postoperative Pain

Recruiting

Conditions: PREG1

Interventions: Drug: Oxytocin
Drug: Carbetocin

First Posted Date: 2024-11-18

Last Posted Date: 2024-11-18

Lead Sponsor: Ankara City Hospital Bilkent

Target Recruit Count: 120

Registration Number: NCT06692621

Locations: 🇹🇷
Ankara Bilkent City Hospital, Ankara, Turkey

OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome

Phase 3

Conditions: Hyperphagia in Prader-Willi Syndrome

Interventions: Drug: Carbetocin

First Posted Date: 2024-05-20

Last Posted Date: 2024-12-04

Lead Sponsor: ACADIA Pharmaceuticals Inc.

Target Recruit Count: 160

Registration Number: NCT06420297

Locations: 🇺🇸
Children's Hospital Colorado, Aurora, Colorado, United States
🇺🇸
SSM Health/Saint Louis University, Saint Louis, Missouri, United States
🇺🇸
Children's of Alabama, Birmingham, Alabama, United States

and more 12 locations

Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery

Not Applicable

Recruiting

Conditions: Post Partum Hemorrhage

Interventions: Drug: Oxytocin
Drug: Carbetocin

First Posted Date: 2024-03-27

Last Posted Date: 2024-11-29

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 160

Registration Number: NCT06333340

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium

Not Applicable

Recruiting

Conditions: Postpartum Hemorrhage

Interventions: Drug: Carbetocin
Drug: Oxytocin
Drug: Ergonovine
Drug: Carboprost

First Posted Date: 2024-02-29

Last Posted Date: 2024-04-12

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 32

Registration Number: NCT06285409

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome

Phase 3

Recruiting

Conditions: Hyperphagia in Prader-Willi Syndrome

Interventions: Drug: Carbetocin
Drug: Placebo

First Posted Date: 2023-12-15

Last Posted Date: 2024-12-04

Lead Sponsor: ACADIA Pharmaceuticals Inc.

Target Recruit Count: 170

Registration Number: NCT06173531

Locations: 🇺🇸
Texas Children's Hospital, Houston, Texas, United States
🇺🇸
Children's of Alabama, Birmingham, Alabama, United States
🇺🇸
Phoenix Children's Hospital, Phoenix, Arizona, United States

and more 23 locations

Carbetocin in the Prevention of Primary Postpartum Haemorrhage

Completed

Conditions: Post Partum Hemorrhage

Interventions: Drug: Carbetocin

First Posted Date: 2023-12-07

Last Posted Date: 2023-12-07

Lead Sponsor: Ministry of Health and Population, Egypt

Target Recruit Count: 244

Registration Number: NCT06159959

Locations: 🇪🇬
Kasr- Alainy Hospitals, Cairo, Egypt

Evaluating Efficacy of Intravenous Carbetocin Versus Intramyometrial Injection of Adrenaline in Reducing Blood Loss

Phase 1

Completed

Conditions: Uterine Fibroid

Interventions: Drug: Carbetocin

First Posted Date: 2023-08-14

Last Posted Date: 2023-10-17

Lead Sponsor: Egymedicalpedia

Target Recruit Count: 62

Registration Number: NCT05986266

Locations: 🇪🇬
Faculty of medicine, Cairo University, Cairo, Egypt

A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects

Phase 1

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: Placebo
Drug: Placebo and Moxifloxacin
Drug: Carbetocin

First Posted Date: 2023-06-29

Last Posted Date: 2023-09-26

Lead Sponsor: Ferring Pharmaceuticals

Target Recruit Count: 40

Registration Number: NCT05924321

Locations: 🇺🇸
Ferring Investigational Site, Tempe, Arizona, United States

Methods Decreasing Bleeding in Open Myomectomy

Phase 4

Recruiting

Conditions: Oxytocin Allergy
Tranexamic Acid Allergy
Ethamsylate Allergy
Myoma
Blood Loss, Surgical
Misoprostol Allergy

Interventions: Drug: combined TXA and ethamsylate
Drug: Bupivacaine Hydrochloride 0.5 % Injectable Solution epinephrine
Device: Tourniquet
Drug: Misoprostol
Drug: Carbetocin
Drug: Oxytocin
Drug: Vasopressin

First Posted Date: 2023-04-10

Last Posted Date: 2023-04-10

Lead Sponsor: Cairo University

Target Recruit Count: 105

Registration Number: NCT05806307

Locations: 🇪🇬
faculty of medicine, Kasr el ainy hospital, Cairo university, Cairo, Egypt

Carbetocin Compared To Oxytocin During Cesarean Delivery

Not yet recruiting

Conditions: Cesarean Delivery

Interventions: Drug: Carbetocin
Drug: oxytocin

First Posted Date: 2023-03-07

Last Posted Date: 2023-03-07

Lead Sponsor: Assiut University

Target Recruit Count: 260

Registration Number: NCT05758012

Locations: 🇰🇼
Munistery of Health Kuwait, Kuwait, Kuwait

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