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Hexamethylenetetramine

Generic Name
Hexamethylenetetramine
Brand Names
Hyophen, Mandelamine, Phosphasal, Urelle, Uribel, Urimar Reformulated Oct 2013, Urin DS, Urogesic Blue Reformulated Apr 2012, Ustell, Utira
Drug Type
Small Molecule
Chemical Formula
C6H12N4
CAS Number
100-97-0
Unique Ingredient Identifier
J50OIX95QV
Background

Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).

Indication

For prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. This drug is not used to treat infection and should only be used after appropriate eradication of infection with antimicrobial agents.

Associated Conditions
Urinary Tract Infection
Clinical Trials
Related News

Methenamine Hippurate Following Intradetrusor OnabotulinumtoxinA Injection

Phase 4
Not yet recruiting
Conditions
Overactive Bladder (OAB)
Urinary Tract Infection (Diagnosis)
Interventions
Drug: Typically prescribed oral antibiotic prophylaxis
First Posted Date
2025-05-01
Last Posted Date
2025-05-01
Lead Sponsor
Women and Infants Hospital of Rhode Island
Target Recruit Count
164
Registration Number
NCT06953271
Locations
🇺🇸

Women & Infants Hospital, Providence, Rhode Island, United States

Is Methenamine Prophylaxis for Urinary Tract Infection After Midurethral Sling As Effective As Antibiotic Prophylaxis?

Not Applicable
Recruiting
Conditions
Urinary Tract Infection (Diagnosis)
Interventions
Other: Antibiotic prophylaxis
First Posted Date
2025-02-05
Last Posted Date
2025-02-07
Lead Sponsor
Atlantic Health System
Target Recruit Count
190
Registration Number
NCT06810687
Locations
🇺🇸

Atlantic Health, Morristown, New Jersey, United States

Vitamin C and Hiprex in rUTI

Early Phase 1
Not yet recruiting
Conditions
Urinary Tract Infections
Interventions
First Posted Date
2024-11-29
Last Posted Date
2025-02-20
Lead Sponsor
University Hospitals of North Midlands NHS Trust
Target Recruit Count
20
Registration Number
NCT06710899
Locations
🇬🇧

University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, Staffordshire, United Kingdom

A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain

Phase 3
Active, not recruiting
Conditions
Interstitial Cystitis
Interventions
Drug: Multimodal Bundle Drugs
Other: Usual Urogynecologic care
Procedure: Operative Cystoscopy
Behavioral: Behavioral health consultation/therapy
Other: Pelvic floor physical therapy
Drug: Bladder Instillation
Drug: Vaginal estrogen
Drug: Amitriptyline/Gabapentin
First Posted Date
2022-12-21
Last Posted Date
2025-03-11
Lead Sponsor
Jocelyn Fitzgerald
Target Recruit Count
26
Registration Number
NCT05658874
Locations
🇺🇸

Magee Womens Hospital, Pittsburgh, Pennsylvania, United States

Efficacy and Mechanism of Action of Methenamine Hippurate (Hiprex™) in Women With Recurring Urinary Tract Infections.

Phase 4
Terminated
Conditions
Urinary Tract Infections
Interventions
First Posted Date
2021-01-14
Last Posted Date
2025-01-07
Lead Sponsor
University of Texas Southwestern Medical Center
Target Recruit Count
14
Registration Number
NCT04709601
Locations
🇺🇸

UT-Southwestern Medical Center, Dallas, Texas, United States

The Effect of Methenamine Hippurate to Reduce Antibiotic Prescribing in Elderly Women With Recurrent UTI

Phase 4
Completed
Conditions
Recurrent Urinary Tract Infection
Interventions
First Posted Date
2019-09-04
Last Posted Date
2024-08-29
Lead Sponsor
University of Oslo
Target Recruit Count
289
Registration Number
NCT04077580
Locations
🇸🇪

Research and Development Primary Health Care, Region Västra Götaland,, Borås, Sweden

🇳🇱

Universitair Medisch Centrum Utrecht, Utrecht, Netherlands

🇵🇱

Medical University of Lodz,, Łódź, Poland

and more 1 locations

Methenamine in a Non-antibiotic, Multimodal Approach to UTI Prevention

Phase 4
Withdrawn
Conditions
Female Urogenital Diseases
UTI
UTI - Lower Urinary Tract Infection
Interventions
Drug: Vaginal estrogen
Dietary Supplement: D-mannose
First Posted Date
2019-06-24
Last Posted Date
2022-07-08
Lead Sponsor
Washington University School of Medicine
Registration Number
NCT03996057

Urinary Track Infection Prevention After Urogynecological Surgery

Phase 2
Completed
Conditions
Urinary Retention Postoperative
Pelvic Organ Prolapse
Urinary Tract Infections
Interventions
Drug: Placebo tablet
First Posted Date
2019-01-28
Last Posted Date
2022-11-14
Lead Sponsor
TriHealth Inc.
Target Recruit Count
185
Registration Number
NCT03818321
Locations
🇺🇸

Cincinnati Urogynecology Associates, Cincinnati, Ohio, United States

Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis

Phase 4
Completed
Conditions
Urinary Tract Infections
Interventions
Drug: Antibiotics
First Posted Date
2017-12-20
Last Posted Date
2021-12-14
Lead Sponsor
Fundação Educacional Serra dos Órgãos
Target Recruit Count
284
Registration Number
NCT03379389
Locations
🇧🇷

Centro Universitário Serra dos Órgãos - UNIFESO, Teresópolis, RJ, Brazil

Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs

Phase 4
Completed
Conditions
Urinary Tract Infections, Recurrent
Interventions
First Posted Date
2017-03-13
Last Posted Date
2020-01-14
Lead Sponsor
NorthShore University HealthSystem
Target Recruit Count
92
Registration Number
NCT03077711
Locations
🇺🇸

NorthShore Univeristy HealthSystem, Skokie, Illinois, United States

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