Trimethoprim
- Generic Name
- Trimethoprim
- Brand Names
- Bactrim, Polytrim, Primsol, Septra, Sulfatrim
- Drug Type
- Small Molecule
- Chemical Formula
- C14H18N4O3
- CAS Number
- 738-70-5
- Unique Ingredient Identifier
- AN164J8Y0X
- Background
Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with sulfamethoxazole due to the...
- Indication
As a monotherapy, trimethoprim is indicated for the treatment of acute episodes of uncomplicated urinary tract infections caused by susceptible bacteria, including E. coli., K. pneumoniae, Enterobacter spp., P. mirabilis, and coagulase-negative Staphylococcus species. In various formulations in combination with sulfamethoxazole, trimethoprim is indicated for...
- Associated Conditions
- Acute Exacerbation of Chronic Bronchitis (AECB) caused by susceptible bacteria, Acute Otitis Media caused by susceptible bacteria, Bacterial Conjunctivitis caused by susceptible bacteria, Blepharoconjunctivitis caused by susceptible bacteria, Brucellosis, Dysentery, Bacillary, Nocardiosis, Pneumocystis Jirovecii Pneumonia, Urinary Tract Infection caused by susceptible bacteria, Bacterial blepharitis caused by susceptible bacteria, Susceptible Cholera, Susceptible Enteritis infectious caused by Shigella flexneri, Susceptible Enteritis infectious caused by Shigella sonnei, Susceptible Travelers' Diarrhea caused by Enterotoxigenic E. Coli (ETEC) Infection, Uncomplicated Urinary Tract Infection caused by susceptible bacteria
- Associated Therapies
- -
Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis
- Conditions
- Interventions
- First Posted Date
- 2024-11-29
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 248
- Registration Number
- NCT06709196
- Locations
- 🇩🇰
Department of Urology, Aalborg University Hospital, Aalborg, Denmark
🇩🇰Department of Urology, Aarhus University Hospital, Aarhus, Denmark
🇩🇰Department of Urology, Rigshospitalet, Copenhagen, Denmark
Effect of Nanotechnology Structured Water Magnalife for the Prevention of Recurrent Urinary Tract Infections.
- Conditions
- Interventions
- First Posted Date
- 2020-03-13
- Last Posted Date
- 2020-03-17
- Lead Sponsor
- University of Sulaimani
- Target Recruit Count
- 437
- Registration Number
- NCT04306731
- Locations
- 🇮🇶
College of Medicine, University of Sulaimani, Sulaymaniyah, Kurdistan Region, Iraq
The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine
- Conditions
- Interventions
- First Posted Date
- 2018-11-19
- Last Posted Date
- 2023-08-14
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 7
- Registration Number
- NCT03746106
- Locations
- 🇺🇸
Jean Mayer USDA Human Nutrition Research Center on Aging, Boston, Massachusetts, United States
S. Aureus Decolonization in HPN Patients.
- First Posted Date
- 2017-06-01
- Last Posted Date
- 2022-05-31
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 63
- Registration Number
- NCT03173053
- Locations
- 🇩🇰
Rigshospitalet, Copenhagen, Denmark
🇩🇰Aalborg Universitetshospital, Aalborg, Denmark
🇳🇱Radboud UMC, Nijmegen, Gelderland, Netherlands
Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs
- Conditions
- Interventions
- First Posted Date
- 2017-03-13
- Last Posted Date
- 2020-01-14
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 92
- Registration Number
- NCT03077711
- Locations
- 🇺🇸
NorthShore Univeristy HealthSystem, Skokie, Illinois, United States
A Non-Interventional Safety Study of Balsamic Bactrim
- First Posted Date
- 2016-09-16
- Last Posted Date
- 2017-11-07
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 52
- Registration Number
- NCT02902640
- Locations
- 🇵🇪
Clinica San Borja; Instituto de Enfermedades Respiratorias EFEH, Lima, Peru
🇵🇪Clinica de Especialidades Medicas, Lima, Peru
🇵🇪Centro de Investigaciones Medicas/Hospital Maria Auxiliadora, San Juan de Miraflores, Peru
A Safety Study of Balsamic Bactrim in Pediatric Participants With Acute Bronchitis
- First Posted Date
- 2016-08-26
- Last Posted Date
- 2019-12-13
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 51
- Registration Number
- NCT02879981
- Locations
- 🇵🇪
Hospital Emergencias Pediatricas; Unidad de Investigación Pediátrica, La Victoria, Peru
🇵🇪Clínica Anglo Americana-CENTRO DE INVESTIGACION PEDIATRIA CAA, San Isidro, Peru
🇵🇪Clinica Internacional, Sede San Borja; Unidad de Investigacion de Clínica Internacional, Lima, Peru
Pentriox - Induction of Oxidative Stress
- Conditions
- Interventions
- First Posted Date
- 2014-07-11
- Last Posted Date
- 2014-07-11
- Lead Sponsor
- Henrik Enghusen Poulsen
- Target Recruit Count
- 90
- Registration Number
- NCT02188472
- Locations
- 🇩🇰
Department of Clinical Pharmacology, Copenhagen, Denmark
Effectiveness of Antibiotics Versus Placebo to Treat Antenatal Hydronephrosis
- Conditions
- Interventions
- First Posted Date
- 2010-06-09
- Last Posted Date
- 2023-10-19
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 160
- Registration Number
- NCT01140516
- Locations
- 🇨🇦
McMaster Children's Hospital, Hamitlon, Ontario, Canada
🇨🇦Sick Kids Hospital for Sick Children, Toronto, Ontario, Canada
Moxifloxacin vs. Polytrim for Conjunctivitis
- First Posted Date
- 2007-12-27
- Last Posted Date
- 2016-01-18
- Lead Sponsor
- University of Rochester
- Target Recruit Count
- 124
- Registration Number
- NCT00581542
- Locations
- 🇺🇸
University of Rochester, Rochester, New York, United States
Drug Development Updates
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