Amoxicillin

Generic Name: Amoxicillin

Brand Names: Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₉N_₃O_₅S

CAS Number: 26787-78-0

Unique Ingredient Identifier: 9EM05410Q9

Background: Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.

Amoxicillin was granted FDA approval on 18 January 1974.

Indication: Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections. Amoxicillin is given with omeprazole in the treatment of Helicobacter pylori (H. pylori) infection.

Amoxicillin is used in combination with vonoprazan and clarithromycin as co-packaged triple therapy or in combination with vonoprazan as co-packaged dual therapy to treat H. pylori infection in adults.

Associated Conditions: Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections

Clinical Trials

The Effect of Vitamin D Supplement as Adjuvant Therapy in Eradication of Helicobacter Pylori Infection

Phase 3

Not yet recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Lansoprazole
Drug: amoxicillin
Drug: clarithromycin
Drug: vitamin D

First Posted Date: 2025-05-09

Last Posted Date: 2025-05-09

Lead Sponsor: Assiut University

Target Recruit Count: 70

Registration Number: NCT06964334

Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis

Phase 2

Not yet recruiting

Conditions: Syphilis, Congenital

Interventions: Drug: Linezolid (LZD)
Drug: Amoxicillin
Drug: Benzathine Penicillin G

First Posted Date: 2025-04-10

Last Posted Date: 2025-05-04

Lead Sponsor: London School of Hygiene and Tropical Medicine

Target Recruit Count: 90

Registration Number: NCT06921213

Locations: 🇿🇦
Stellenbosch, Stellenbosch, South Africa
🇮🇩
Universitas Indonesia, Jakarta, Indonesia
🇲🇼
Malawi Liverpool Wellcome Programme, Blantyre, Malawi

Zuojin Wan Combined with Vonoprazan-Amoxicillin Dual Therapy in H.Pylori Eradication

Early Phase 1

Not yet recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Vonoprazan
Drug: Amoxicillin
Drug: Zuojin Wan

First Posted Date: 2025-03-28

Last Posted Date: 2025-03-28

Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Target Recruit Count: 136

Registration Number: NCT06901375

Locations: 🇨🇳
Nanjing First Hospitai, Nanjing, Jiangsu, China

Oral Amoxicillin Compared to Penicillin G Benzathine for the Treatment of Acquired Syphilis.

Phase 3

Active, not recruiting

Conditions: Syphilis Acquired

Interventions: Drug: Amoxicillin
Drug: Penicillin G, Benzathine

First Posted Date: 2025-03-14

Last Posted Date: 2025-03-14

Lead Sponsor: Hospital de Niños R. Gutierrez de Buenos Aires

Target Recruit Count: 120

Registration Number: NCT06877351

Locations: 🇦🇷
Hospital de Niños Ricardo Gutierrez, Buenos Aires City, Buenos Aires, Argentina

Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition

Not Applicable

Not yet recruiting

Conditions: Severe Acute Malnutrition
Cognitive Impairment
Kwashiorkor
Severe Wasting

Interventions: Dietary Supplement: MFGM-RUTF (milk fat globule membrane ready-to-use therapeutic food)
Dietary Supplement: S-RUTF (standard ready-to-use therapeutic food)
Drug: Amoxicillin
Drug: Sulfadoxine (12.5 mg)/Pyrimethamine (250 mg)
Drug: Artemether+Lumefantrine

First Posted Date: 2025-03-11

Last Posted Date: 2025-03-11

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 1600

Registration Number: NCT06869850

Locations: 🇸🇱
Bandajuma, Bandajuma, Pujehun, Sierra Leone
🇸🇱
Bandasuma, Bandasuma, Pujehun, Sierra Leone
🇸🇱
Bendu Malen, Bendu Malen, Pujehun, Sierra Leone

and more 7 locations