MedPath

Sulfadoxine

Generic Name
Sulfadoxine
Drug Type
Small Molecule
Chemical Formula
C12H14N4O4S
CAS Number
2447-57-6
Unique Ingredient Identifier
88463U4SM5
Background

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.

Indication

Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well.

Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.

Associated Conditions
Malaria, Malaria caused by Plasmodium falciparum, Acute, uncomplicated Malaria caused by plasmodium falciparum
Clinical Trials
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Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition

Not Applicable
Not yet recruiting
Conditions
Severe Acute Malnutrition
Cognitive Impairment
Kwashiorkor
Severe Wasting
Interventions
Dietary Supplement: MFGM-RUTF (milk fat globule membrane ready-to-use therapeutic food)
Dietary Supplement: S-RUTF (standard ready-to-use therapeutic food)
Drug: Artemether+Lumefantrine
First Posted Date
2025-03-11
Last Posted Date
2025-03-11
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
1600
Registration Number
NCT06869850
Locations
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Bandajuma, Bandajuma, Pujehun, Sierra Leone

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Bandasuma, Bandasuma, Pujehun, Sierra Leone

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Bendu Malen, Bendu Malen, Pujehun, Sierra Leone

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Bioequivalence Study of Sulfadoxine/Pyrimethamine 500/25 mg Dispersible Tablet

First Posted Date
2024-07-26
Last Posted Date
2024-07-26
Lead Sponsor
Swiss Pharma Nigeria Limited
Target Recruit Count
46
Registration Number
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Locations
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International Pharmaceutical Research Center (IPRC) Queen Rania Street - Sport City Circle,, Amman, Jordan

Eggs for Gut Health

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Completed
Conditions
Moderate Acute Malnutrition
Severe Acute Malnutrition
Stunting
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Interventions
Dietary Supplement: Whole egg powder
Dietary Supplement: Corn powder
Dietary Supplement: Supercereal Plus
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First Posted Date
2023-08-21
Last Posted Date
2025-02-06
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
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Registration Number
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Bandajuma, Bandajuma, Southern, Sierra Leone

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Bendu Maleh, Bendu, Southern, Sierra Leone

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Comparing Chemoprevention Drugs for School-based Malaria Control

Phase 4
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Conditions
Anemia in Children
Malaria,Falciparum
Interventions
First Posted Date
2023-08-07
Last Posted Date
2023-08-07
Lead Sponsor
University of Maryland, Baltimore
Target Recruit Count
646
Registration Number
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Kamuzu University of Health Sciences, Blantyre, Malawi

Improving Cognition and Gestational Duration With Targeted Nutrition

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Recruiting
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Malnutrition in Pregnancy
Preterm Birth
Antepartum Depression
Child Development
Postpartum Depression
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Dietary Supplement: M-RUSF+ (Maternal Ready-to-Use Supplementary Food + DHA/EPA/choline)
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Last Posted Date
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Sahn Malen, Sahn, Southern, Sierra Leone

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Zimmi, Zimmi, Southern, Sierra Leone

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First Posted Date
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Lead Sponsor
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Target Recruit Count
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Registration Number
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Perennial Malaria Chemoprevention (PMC) in Côte D'Ivoire

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2025-01-09
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Target Recruit Count
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Chemoprevention Efficacy Study in Burkina Faso

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Conditions
Malaria
Interventions
First Posted Date
2022-07-28
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2023-11-01
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Registration Number
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Unité de Recherche Clinique de Nanoro, Nanoro, Burkina Faso

Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan

Phase 3
Active, not recruiting
Conditions
Malaria
Interventions
First Posted Date
2022-07-25
Last Posted Date
2024-03-25
Lead Sponsor
Malaria Consortium
Target Recruit Count
3575
Registration Number
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Locations
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Aweil South, Aweil, Northern Bahr El Gazal, South Sudan

Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy

Phase 3
Active, not recruiting
Conditions
Malaria
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First Posted Date
2022-06-22
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2024-08-29
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Registration Number
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Locations
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Papua New Guinea Institute of Medical Research, Madang, Madang Province, Papua New Guinea

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